3snp
From Proteopedia
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==Crystal structure analysis of iron regulatory protein 1 in complex with ferritin H IRE RNA== | ==Crystal structure analysis of iron regulatory protein 1 in complex with ferritin H IRE RNA== | ||
| - | <StructureSection load='3snp' size='340' side='right' caption='[[3snp]], [[Resolution|resolution]] 2.80Å' scene=''> | + | <StructureSection load='3snp' size='340' side='right'caption='[[3snp]], [[Resolution|resolution]] 2.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3snp]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3snp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ipy 2ipy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SNP FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3snp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3snp OCA], [https://pdbe.org/3snp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3snp RCSB], [https://www.ebi.ac.uk/pdbsum/3snp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3snp ProSAT]</span></td></tr> | |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| - | + | == Function == | |
| - | = | + | [https://www.uniprot.org/uniprot/ACOHC_RABIT ACOHC_RABIT] Bifunctional iron sensor that switches between 2 activities depending on iron availability (By similarity). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:17185597). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:17185597).[UniProtKB:P21399]<ref>PMID:17185597</ref> Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.[UniProtKB:P21399] |
| - | Iron | + | |
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==See Also== | ==See Also== | ||
| - | *[[Aconitase|Aconitase]] | + | *[[Aconitase 3D structures|Aconitase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
| - | [[Category: | + | [[Category: Xenopus laevis]] |
| - | [[Category: | + | [[Category: Selezneva AI]] |
| - | [[Category: | + | [[Category: Volz K]] |
| - | [[Category: | + | [[Category: Walden WE]] |
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Current revision
Crystal structure analysis of iron regulatory protein 1 in complex with ferritin H IRE RNA
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