This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

3p68

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Current revision

Time-dependent and Protein-directed In Situ Growth of Gold Nanoparticles in a Single Crystal of Lysozyme

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3p68"

@@ Line 1: / Line 1: @@
 ==Time-dependent and Protein-directed In Situ Growth of Gold Nanoparticles in a Single Crystal of Lysozyme==
-<StructureSection load='3p68' size='340' side='right' caption='[[3p68]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+<StructureSection load='3p68' size='340' side='right'caption='[[3p68]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3p68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P68 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3p68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P68 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU3:GOLD+3++ION'>AU3</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3p4z|3p4z]], [[3p64|3p64]], [[3p65|3p65]], [[3p66|3p66]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU3:GOLD+3++ION'>AU3</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p68 OCA], [https://pdbe.org/3p68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p68 RCSB], [https://www.ebi.ac.uk/pdbsum/3p68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p68 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p68 RCSB], [http://www.ebi.ac.uk/pdbsum/3p68 PDBsum]</span></td></tr>
 </table>
-<div style="background-color:#fffaf0;">
+== Function ==
-== Publication Abstract from PubMed ==
+[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
-Gold nanoparticles are useful in biomedical applications due to their distinct optical properties and high chemical stability. Reports of the biogenic formation of gold colloids from gold complexes has also led to an increased level of interest in the biomineralization of gold. However, the mechanism responsible for biomolecule-directed gold nanoparticle formation remains unclear due to the lack of structural information about biological systems and the fast kinetics of biomimetic chemical systems in solution. Here we show that intact single crystals of lysozyme can be used to study the time-dependent, protein-directed growth of gold nanoparticles. The protein crystals slow down the growth of the gold nanoparticles, allowing detailed kinetic studies to be carried out, and permit a three-dimensional structural characterization that would be difficult to achieve in solution. Furthermore, we show that additional chemical species can be used to fine-tune the growth rate of the gold nanoparticles.
-Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme.,Wei H, Wang Z, Zhang J, House S, Gao YG, Yang L, Robinson H, Tan LH, Xing H, Hou C, Robertson IM, Zuo JM, Lu Y Nat Nanotechnol. 2011 Feb;6(2):93-7. Epub 2011 Jan 30. PMID:21278750<ref>PMID:21278750</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
 ==See Also==
@@ Line 24: / Line 18: @@
 </StructureSection>
 [[Category: Gallus gallus]]
-[[Category: Lysozyme]]
+[[Category: Large Structures]]
-[[Category: Gao, Y G]]
+[[Category: Gao Y-G]]
-[[Category: Hou, C]]
+[[Category: Hou C]]
-[[Category: House, S]]
+[[Category: House S]]
-[[Category: Lu, Y]]
+[[Category: Lu Y]]
-[[Category: Robertson, I M]]
+[[Category: Robertson IM]]
-[[Category: Robinson, H]]
+[[Category: Robinson H]]
-[[Category: Tan, L H]]
+[[Category: Tan LH]]
-[[Category: Wang, Z]]
+[[Category: Wang Z]]
-[[Category: Wei, H]]
+[[Category: Wei H]]
-[[Category: Xing, H]]
+[[Category: Xing H]]
-[[Category: Yang, L]]
+[[Category: Yang L]]
-[[Category: Zhang, J]]
+[[Category: Zhang J]]
-[[Category: Zuo, J M]]
+[[Category: Zuo J-M]]
-[[Category: Binding site]]
-[[Category: Bio-nano hybrid]]
-[[Category: Gold nanoparticle]]
-[[Category: Hydrolase]]
-[[Category: Porous material]]

3p68

From Proteopedia

Current revision

Time-dependent and Protein-directed In Situ Growth of Gold Nanoparticles in a Single Crystal of Lysozyme

Structural highlights

Function

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox