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1nkl

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[[Image:1nkl.gif|left|200px]]
 
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{{Structure
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==NK-LYSIN FROM PIG, NMR, 20 STRUCTURES==
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|PDB= 1nkl |SIZE=350|CAPTION= <scene name='initialview01'>1nkl</scene>
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<StructureSection load='1nkl' size='340' side='right'caption='[[1nkl]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1nkl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NKL FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nkl OCA], [https://pdbe.org/1nkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nkl RCSB], [https://www.ebi.ac.uk/pdbsum/1nkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nkl ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NKL_PIG NKL_PIG] May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nk/1nkl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nkl ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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NK-lysin is the first representative of a family of sequence related proteins--saposins, surfactant-associated protein B, pore forming amoeba proteins, and domains of acid sphingomyelinase, acyloxyacylhydrolase and plant aspartic proteinases--for which a structure has been determined.
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'''NK-LYSIN FROM PIG, NMR, 20 STRUCTURES'''
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Saposin fold revealed by the NMR structure of NK-lysin.,Liepinsh E, Andersson M, Ruysschaert JM, Otting G Nat Struct Biol. 1997 Oct;4(10):793-5. PMID:9334742<ref>PMID:9334742</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1nkl" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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NK-lysin is the first representative of a family of sequence related proteins--saposins, surfactant-associated protein B, pore forming amoeba proteins, and domains of acid sphingomyelinase, acyloxyacylhydrolase and plant aspartic proteinases--for which a structure has been determined.
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*[[Lysin 3D structures|Lysin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1NKL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKL OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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Saposin fold revealed by the NMR structure of NK-lysin., Liepinsh E, Andersson M, Ruysschaert JM, Otting G, Nat Struct Biol. 1997 Oct;4(10):793-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9334742 9334742]
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[[Category: Single protein]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Liepinsh, E.]]
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[[Category: Liepinsh E]]
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[[Category: Otting, G.]]
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[[Category: Otting G]]
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[[Category: antibacterial peptide]]
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[[Category: saposin fold]]
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[[Category: tumourolytic peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:58:03 2008''
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Current revision

NK-LYSIN FROM PIG, NMR, 20 STRUCTURES

PDB ID 1nkl

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