3uhm

<StructureSection load='3uhm' size='340' side='right' caption='[[3uhm]], [[Resolution|resolution]] 1.26&Aring;' scene=''>

<table><tr><td colspan='2'>[[3uhm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UHM FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GAI:GUANIDINE'>GAI</scene>, <scene name='pdbligand=RFN:(2R)-N-HYDROXY-2-METHYL-2-(METHYLSULFONYL)-4-(2-OXO-4-PHENYLPYRIDIN-1(2H)-YL)BUTANAMIDE'>RFN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpxC, envA, PA4406 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uhm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uhm RCSB], [http://www.ebi.ac.uk/pdbsum/3uhm PDBsum]</span></td></tr>

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== Publication Abstract from PubMed ==

The synthesis and biological activity of a new series of LpxC inhibitors represented by pyridone methylsulfone hydroxamate 2a is presented. Members of this series have improved solubility and free fraction when compared to compounds in the previously described biphenyl methylsulfone hydroxamate series, and they maintain superior Gram-negative antibacterial activity to comparator agents.

 

Pyridone Methylsulfone Hydroxamate LpxC Inhibitors for the Treatment of Serious Gram-Negative Infections.,Montgomery JI, Brown MF, Reilly U, Price LM, Abramite JA, Arcari J, Barham RA, Che Y, Chen JM, Chung SW, Collantes EM, Desbonnet C, Doroski M, Doty J, Engtrakul JJ, Harris TM, Huband M, Knafels JD, Leach KL, Liu S, Marfat A, McAllister LA, McElroy E, Menard C, Mitton-Fry M, Mullins L, Noe MC, O'Donnell JP, Oliver R, Penzien J, Plummer M, Shanmugasundaram V, Thoma C, Tomaras AP, Uccello DP, Vaz AD, Wishka DG J Med Chem. 2012 Jan 18. PMID:22257165<ref>PMID:22257165</ref>

 

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

[[Category: Liu, S]]

[[Category: Montgomery, J]]

[[Category: Hydrolase-hydrolase inhibitor complex]]