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4et0
From Proteopedia
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==Crystal structure of circularly permuted human asparaginase-like protein 1== | ==Crystal structure of circularly permuted human asparaginase-like protein 1== | ||
| - | <StructureSection load='4et0' size='340' side='right' caption='[[4et0]], [[Resolution|resolution]] 3.30Å' scene=''> | + | <StructureSection load='4et0' size='340' side='right'caption='[[4et0]], [[Resolution|resolution]] 3.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4et0]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4et0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ET0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ET0 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4et0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4et0 OCA], [https://pdbe.org/4et0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4et0 RCSB], [https://www.ebi.ac.uk/pdbsum/4et0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4et0 ProSAT]</span></td></tr> |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| - | + | == Function == | |
| - | = | + | [https://www.uniprot.org/uniprot/ASGL1_HUMAN ASGL1_HUMAN] Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.<ref>PMID:19839645</ref> |
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| - | + | ==See Also== | |
| - | + | *[[Asparaginase 3D structures|Asparaginase 3D structures]] | |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Asparaginase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Li WZ]] |
| - | [[Category: | + | [[Category: Yogesha SD]] |
| - | [[Category: | + | [[Category: Zhang Y]] |
Current revision
Crystal structure of circularly permuted human asparaginase-like protein 1
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