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4awn

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==Structure of recombinant human DNase I (rhDNaseI) in complex with Magnesium and Phosphate.==
==Structure of recombinant human DNase I (rhDNaseI) in complex with Magnesium and Phosphate.==
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<StructureSection load='4awn' size='340' side='right' caption='[[4awn]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='4awn' size='340' side='right'caption='[[4awn]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4awn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AWN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4awn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AWN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxyribonuclease_I Deoxyribonuclease I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.21.1 3.1.21.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4awn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4awn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4awn RCSB], [http://www.ebi.ac.uk/pdbsum/4awn PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4awn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4awn OCA], [https://pdbe.org/4awn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4awn RCSB], [https://www.ebi.ac.uk/pdbsum/4awn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4awn ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DNAS1_HUMAN DNAS1_HUMAN] Systemic lupus erythematosus. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/DNAS1_HUMAN DNAS1_HUMAN] Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4awn" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Deoxyribonuclease I]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bourne, Y]]
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[[Category: Large Structures]]
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[[Category: Lazarus, R A]]
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[[Category: Bourne Y]]
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[[Category: Noguere, C]]
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[[Category: Lazarus RA]]
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[[Category: Parsiegla, G]]
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[[Category: Noguere C]]
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[[Category: Santell, L]]
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[[Category: Parsiegla G]]
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[[Category: Endonuclease]]
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[[Category: Santell L]]
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[[Category: Hydrolase]]
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[[Category: Pulmozyme]]
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Current revision

Structure of recombinant human DNase I (rhDNaseI) in complex with Magnesium and Phosphate.

PDB ID 4awn

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