1ntg

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[[Image:1ntg.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of the EMAP II-like Cytokine Released from human tyrosyl-tRNA Synthetase==
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|PDB= 1ntg |SIZE=350|CAPTION= <scene name='initialview01'>1ntg</scene>, resolution 2.21&Aring;
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<StructureSection load='1ntg' size='340' side='right'caption='[[1ntg]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1ntg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NTG FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
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|GENE= YARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ntg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntg OCA], [https://pdbe.org/1ntg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ntg RCSB], [https://www.ebi.ac.uk/pdbsum/1ntg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ntg ProSAT]</span></td></tr>
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}}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN] Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC) [MIM:[https://omim.org/entry/608323 608323]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.<ref>PMID:16429158</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/1ntg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ntg ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of the EMAP II-like Cytokine Released from human tyrosyl-tRNA Synthetase'''
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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== References ==
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==Disease==
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<references/>
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Known disease associated with this structure: Charcot-Marie-Tooth disease, dominant intermediate C OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603623 603623]]
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__TOC__
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</StructureSection>
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==About this Structure==
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1NTG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTG OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Tyrosine--tRNA ligase]]
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[[Category: Mcree DE]]
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[[Category: Mcree, D E.]]
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[[Category: Schimmel P]]
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[[Category: Schimmel, P.]]
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[[Category: Skene RJ]]
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[[Category: Skene, R J.]]
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[[Category: Yang X-L]]
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[[Category: Yang, X L.]]
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[[Category: beta barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:01:26 2008''
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Current revision

Crystal Structure of the EMAP II-like Cytokine Released from human tyrosyl-tRNA Synthetase

PDB ID 1ntg

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