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1nth

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[[Image:1nth.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the methanosarcina barkeri monomethylamine methyltransferase (MTMB)==
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|PDB= 1nth |SIZE=350|CAPTION= <scene name='initialview01'>1nth</scene>, resolution 1.55&Aring;
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<StructureSection load='1nth' size='340' side='right'caption='[[1nth]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=BGX:4-METHYL-PYRROLINE-5-CARBOXYLIC ACID'>BGX</scene>
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<table><tr><td colspan='2'>[[1nth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l2r 1l2r]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NTH FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nth OCA], [https://pdbe.org/1nth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nth RCSB], [https://www.ebi.ac.uk/pdbsum/1nth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nth ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''Crystal structure of the methanosarcina barkeri monomethylamine methyltransferase (MTMB)'''
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[https://www.uniprot.org/uniprot/MTMB1_METBA MTMB1_METBA] Catalyzes the transfer of the methyl group from monomethylamine to the corrinoid cofactor of MtmC (MtmC1 or MtmC2).<ref>PMID:9642198</ref> <ref>PMID:9195968</ref>
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== References ==
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<references/>
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==Overview==
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__TOC__
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Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkeri monomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead it appears consistent with a lysine in amide-linkage to (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino acid be named l-pyrrolysine.
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</StructureSection>
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[[Category: Large Structures]]
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==About this Structure==
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1NTH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. This structure supersedes the now removed PDB entry 1L2R. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTH OCA].
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==Reference==
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A new UAG-encoded residue in the structure of a methanogen methyltransferase., Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK, Science. 2002 May 24;296(5572):1462-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12029132 12029132]
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[[Category: Methanosarcina barkeri]]
[[Category: Methanosarcina barkeri]]
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[[Category: Single protein]]
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[[Category: Chan MK]]
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[[Category: Chan, M K.]]
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[[Category: Ferguson TK]]
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[[Category: Ferguson, T K.]]
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[[Category: Gong W]]
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[[Category: Gong, W.]]
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[[Category: Hao B]]
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[[Category: Hao, B.]]
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[[Category: James CM]]
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[[Category: James, C M.]]
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[[Category: Krzycki JA]]
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[[Category: Krzycki, J A.]]
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[[Category: BGX]]
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[[Category: tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:01:28 2008''
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Current revision

Crystal structure of the methanosarcina barkeri monomethylamine methyltransferase (MTMB)

PDB ID 1nth

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