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3uc9

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==Crystal Structure of Yeast Irc6p - A Novel Type of Conserved Clathrin Accessory Protein==
==Crystal Structure of Yeast Irc6p - A Novel Type of Conserved Clathrin Accessory Protein==
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<StructureSection load='3uc9' size='340' side='right' caption='[[3uc9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3uc9' size='340' side='right'caption='[[3uc9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3uc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UC9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3uc9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UC9 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IRC6, YFR043C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uc9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uc9 RCSB], [http://www.ebi.ac.uk/pdbsum/3uc9 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uc9 OCA], [https://pdbe.org/3uc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uc9 RCSB], [https://www.ebi.ac.uk/pdbsum/3uc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uc9 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/IRC6_YEAST IRC6_YEAST] Involved in gross chromosomal rearrangements (GCRs) and telomere healing.<ref>PMID:20194442</ref>
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Clathrin coat accessory proteins play key roles in transport mediated by clathrin-coated vesicles. Yeast Irc6p and the related mammalian p34 are putative clathrin accessory proteins that interact with clathrin adaptor complexes. Here we present evidence that Irc6p functions in clathrin-mediated traffic between the TGN and endosomes, linking clathrin adaptor complex AP-1 and the Rab GTPase Ypt31p. The crystal structure of the Irc6p N-terminal domain revealed a G protein fold most related to small G proteins of the Rab and Arf families. However, Irc6p lacks G protein signature motifs and high-affinity GTP binding. Also, mutant Irc6p lacking candidate GTP-binding residues retained function. Mammalian p34 rescued growth defects in irc6 cells indicating functional conservation, and modeling predicted a similar N-terminal fold in p34. Irc6p and p34 also contain functionally conserved C-terminal regions. Irc6p/p34-related proteins with the same two-part architecture are encoded in genomes of species as diverse as plants and humans. Together these results define Irc6p/p34 as a novel type of conserved clathrin accessory protein and founding members of a new G protein-like family.
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Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins.,Gorynia S, Lorenz TC, Costaguta G, Daboussi L, Cascio D, Payne GS Mol Biol Cell. 2012 Sep 19. PMID:22993212<ref>PMID:22993212</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Saccharomyces cerevisiae s288c]]
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[[Category: Large Structures]]
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[[Category: Cascio, D]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Gorynia, S]]
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[[Category: Cascio D]]
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[[Category: Payne, G S]]
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[[Category: Gorynia S]]
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[[Category: Sawaya, M R]]
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[[Category: Payne GS]]
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[[Category: Clathrin accessory factor]]
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[[Category: Sawaya MR]]
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[[Category: Recombination]]
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[[Category: Rossmann-fold]]
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Current revision

Crystal Structure of Yeast Irc6p - A Novel Type of Conserved Clathrin Accessory Protein

PDB ID 3uc9

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