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4b6h
From Proteopedia
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==Structure of hDcp1a in complex with proline rich sequence of PNRC2== | ==Structure of hDcp1a in complex with proline rich sequence of PNRC2== | ||
| - | <StructureSection load='4b6h' size='340' side='right' caption='[[4b6h]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='4b6h' size='340' side='right'caption='[[4b6h]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4b6h]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4b6h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B6H FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b6h OCA], [https://pdbe.org/4b6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b6h RCSB], [https://www.ebi.ac.uk/pdbsum/4b6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b6h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DCP1A_HUMAN DCP1A_HUMAN] Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.<ref>PMID:11836524</ref> <ref>PMID:12417715</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4b6h" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Lai T]] |
| - | [[Category: | + | [[Category: Song H]] |
| - | + | ||
Current revision
Structure of hDcp1a in complex with proline rich sequence of PNRC2
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