3upi
From Proteopedia
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==Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors== | ==Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors== | ||
| - | <StructureSection load='3upi' size='340' side='right' caption='[[3upi]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='3upi' size='340' side='right'caption='[[3upi]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3upi]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3upi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_isolate_HC-J4 Hepatitis C virus isolate HC-J4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UPI FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0C2:(3S)-6-(2,5-DIFLUOROBENZYL)-3-METHYL-N-(METHYLSULFONYL)-8-(2-OXO-1,2-DIHYDROPYRIDIN-3-YL)-3,6-DIHYDRO-2H-FURO[2,3-E]INDOLE-7-CARBOXAMIDE'>0C2</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0C2:(3S)-6-(2,5-DIFLUOROBENZYL)-3-METHYL-N-(METHYLSULFONYL)-8-(2-OXO-1,2-DIHYDROPYRIDIN-3-YL)-3,6-DIHYDRO-2H-FURO[2,3-E]INDOLE-7-CARBOXAMIDE'>0C2</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3upi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3upi OCA], [https://pdbe.org/3upi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3upi RCSB], [https://www.ebi.ac.uk/pdbsum/3upi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3upi ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3upi" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[RNA polymerase|RNA polymerase]] | + | *[[RNA polymerase 3D structures|RNA polymerase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Hepatitis | + | [[Category: Hepatitis C virus isolate HC-J4]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Duca | + | [[Category: Duca JS]] |
| - | [[Category: Kozlowski | + | [[Category: Kozlowski JA]] |
| - | [[Category: Lesburg | + | [[Category: Lesburg CA]] |
| - | [[Category: Njoroge | + | [[Category: Njoroge FG]] |
| - | [[Category: Rosenblum | + | [[Category: Rosenblum SB]] |
| - | [[Category: Velazquez | + | [[Category: Velazquez F]] |
| - | [[Category: Venkataraman | + | [[Category: Venkataraman S]] |
| - | + | ||
Current revision
Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors
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