1nxm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:00, 14 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1nxm.gif|left|200px]]
 
-
{{Structure
+
==The high resolution structures of RmlC from Streptococcus suis==
-
|PDB= 1nxm |SIZE=350|CAPTION= <scene name='initialview01'>1nxm</scene>, resolution 1.30&Aring;
+
<StructureSection load='1nxm' size='340' side='right'caption='[[1nxm]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1nxm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_suis Streptococcus suis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NXM FirstGlance]. <br>
-
|ACTIVITY= [http://en.wikipedia.org/wiki/dTDP-4-dehydrorhamnose_3,5-epimerase dTDP-4-dehydrorhamnose 3,5-epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.3.13 5.1.3.13]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
-
|GENE= rmlc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1307 Streptococcus suis])
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nxm OCA], [https://pdbe.org/1nxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nxm RCSB], [https://www.ebi.ac.uk/pdbsum/1nxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nxm ProSAT]</span></td></tr>
-
}}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q8GIQ0_STRSU Q8GIQ0_STRSU]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nx/1nxm_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nxm ConSurf].
 +
<div style="clear:both"></div>
-
'''The high resolution structures of RmlC from Streptococcus suis'''
+
==See Also==
-
 
+
*[[RmlC|RmlC]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
Nature achieves the epimerization of carbohydrates by a variety of chemical routes. One common route is that performed by the class of enzyme defined by dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase (RmlC) from the rhamnose pathway. Earlier studies failed to identify the key residues in catalysis. We report the 1.3 A structure of RmlC from Streptococcus suis type 2 and its complexes with dTDP-D-glucose and dTDP-D-xylose. The streptococcal RmlC enzymes belong to a separate subgroup, sharing only 25% identity with RmlC from other bacteria, yet the S. suis enzyme has similar kinetic properties and structure to other RmlC enzymes. Structure, sequence alignment, and mutational analysis have now allowed reliable identification of the catalytic residues and their roles.
+
[[Category: Large Structures]]
-
 
+
-
==About this Structure==
+
-
1NXM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_suis Streptococcus suis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NXM OCA].
+
-
 
+
-
==Reference==
+
-
High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme., Dong C, Major LL, Allen A, Blankenfeldt W, Maskell D, Naismith JH, Structure. 2003 Jun;11(6):715-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12791259 12791259]
+
-
[[Category: Single protein]]
+
[[Category: Streptococcus suis]]
[[Category: Streptococcus suis]]
-
[[Category: dTDP-4-dehydrorhamnose 3,5-epimerase]]
+
[[Category: Allen A]]
-
[[Category: Allen, A.]]
+
[[Category: Blankenfeldt W]]
-
[[Category: Blankenfeldt, W.]]
+
[[Category: Dong C]]
-
[[Category: Dong, C.]]
+
[[Category: Major LL]]
-
[[Category: Major, L L.]]
+
[[Category: Maskell D]]
-
[[Category: Maskell, D.]]
+
[[Category: Naismith JH]]
-
[[Category: Naismith, J H.]]
+
-
[[Category: jelly roll-like structure; beta sheet]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:03:01 2008''
+

Current revision

The high resolution structures of RmlC from Streptococcus suis

PDB ID 1nxm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nxm"
Personal tools