4apb

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==Crystal structure of Mycobacterium tuberculosis fumarase (Rv1098c) S318C in complex with fumarate==
==Crystal structure of Mycobacterium tuberculosis fumarase (Rv1098c) S318C in complex with fumarate==
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<StructureSection load='4apb' size='340' side='right' caption='[[4apb]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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<StructureSection load='4apb' size='340' side='right'caption='[[4apb]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4apb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4APB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4apb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4APB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUM:FUMARIC+ACID'>FUM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4adl|4adl]], [[4adm|4adm]], [[4apa|4apa]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUM:FUMARIC+ACID'>FUM</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4apb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apb OCA], [https://pdbe.org/4apb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4apb RCSB], [https://www.ebi.ac.uk/pdbsum/4apb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4apb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4apb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4apb RCSB], [http://www.ebi.ac.uk/pdbsum/4apb PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FUMC_MYCTU FUMC_MYCTU] Catalyzes the reversible addition of water to fumarate to give L-malate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4apb" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fumarate hydratase]]
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Alzari, P M]]
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[[Category: Alzari PM]]
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[[Category: Bellinzoni, M]]
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[[Category: Bellinzoni M]]
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[[Category: Haouz, A]]
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[[Category: Haouz A]]
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[[Category: Mechaly, A E]]
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[[Category: Mechaly AE]]
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[[Category: Hydrolase]]
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[[Category: Metabolism]]
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Crystal structure of Mycobacterium tuberculosis fumarase (Rv1098c) S318C in complex with fumarate

PDB ID 4apb

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