1nzg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:00, 14 February 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1nzg.gif|left|200px]]
 
-
{{Structure
+
==Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine==
-
|PDB= 1nzg |SIZE=350|CAPTION= <scene name='initialview01'>1nzg</scene>, resolution 1.60&Aring;
+
<StructureSection load='1nzg' size='340' side='right'caption='[[1nzg]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1nzg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NZG FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3ME:2-O-{2-[2-(DIMETHYLAMINO)ETHOXY]ETHYL}-5-METHYLURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>3ME</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nzg OCA], [https://pdbe.org/1nzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nzg RCSB], [https://www.ebi.ac.uk/pdbsum/1nzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nzg ProSAT]</span></td></tr>
-
 
+
</table>
-
'''Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine'''
+
__TOC__
-
 
+
</StructureSection>
-
 
+
[[Category: Large Structures]]
-
==Overview==
+
[[Category: Egli M]]
-
[structure: see text] Oligonucleotides with a novel, 2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] (2'-O-DMAEOE) modification have been synthesized. This modification, a cationic analogue of the 2'-O-(2-methoxyethyl) (2'-O-MOE) modification, exhibits high binding affinity to target RNA (but not to DNA) and exceptional resistance to nuclease degradation. Analysis of the crystal structure of a self-complementary oligonucleotide containing a single 2'-O-DMAEOE modification explains the importance of charge factors and gauche effects on the observed antisense properties. 2'-O-DMAEOE modified oligonucleotides are ideal candidates for antisense drugs.
+
[[Category: Manoharan M]]
-
 
+
[[Category: Minasov G]]
-
==About this Structure==
+
[[Category: Prakash TP]]
-
1NZG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZG OCA].
+
[[Category: Prhavc M]]
-
 
+
-
==Reference==
+
-
2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects., Prhavc M, Prakash TP, Minasov G, Cook PD, Egli M, Manoharan M, Org Lett. 2003 Jun 12;5(12):2017-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12790517 12790517]
+
-
[[Category: Protein complex]]
+
-
[[Category: Egli, M.]]
+
-
[[Category: Manoharan, M.]]
+
-
[[Category: Minasov, G.]]
+
-
[[Category: Prakash, T P.]]
+
-
[[Category: Prhavc, M.]]
+
-
[[Category: 2'-modified oligonucleotide]]
+
-
[[Category: a-dna]]
+
-
[[Category: crystal structure]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:03:43 2008''
+

Current revision

Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine

PDB ID 1nzg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nzg"
Personal tools