4frj

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==Crystal structure of BACE1 in complex with aminooxazoline xanthene 9l==
==Crystal structure of BACE1 in complex with aminooxazoline xanthene 9l==
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<StructureSection load='4frj' size='340' side='right' caption='[[4frj]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='4frj' size='340' side='right'caption='[[4frj]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4frj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FRJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4frj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FRJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DWB:(4S)-2-(5-CHLORO-2-FLUOROPHENYL)-7-METHOXYSPIRO[1,3-OXAZOLE-4,9-XANTHEN]-2-AMINE'>DWB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fri|4fri]], [[4frk|4frk]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DWB:(4S)-2-(5-CHLORO-2-FLUOROPHENYL)-7-METHOXYSPIRO[1,3-OXAZOLE-4,9-XANTHEN]-2-AMINE'>DWB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4frj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4frj OCA], [https://pdbe.org/4frj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4frj RCSB], [https://www.ebi.ac.uk/pdbsum/4frj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4frj ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4frj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4frj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4frj RCSB], [http://www.ebi.ac.uk/pdbsum/4frj PDBsum]</span></td></tr>
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</table>
</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4frj" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Beta secretase|Beta secretase]]
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*[[Beta secretase 3D structures|Beta secretase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Large Structures]]
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[[Category: Long, A M]]
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[[Category: Long AM]]
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[[Category: Whittington, D A]]
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[[Category: Whittington DA]]
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[[Category: Alzheimer's disease]]
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[[Category: Aspartic protease]]
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[[Category: Hydrolase-inhibitor complex]]
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[[Category: Membrane protein]]
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Crystal structure of BACE1 in complex with aminooxazoline xanthene 9l

PDB ID 4frj

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