4a09

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==STRUCTURE OF HSDDB1-DRDDB2 BOUND TO A 15 BP CPD-DUPLEX (PURINE AT D-1 POSITION) AT 3.1 A RESOLUTION (CPD 2)==
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<StructureSection load='4a09' size='340' side='right' caption='[[4a09]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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==Structure of hsDDB1-drDDB2 bound to a 15 bp CPD-duplex (purine at D-1 position) at 3.1 A resolution (CPD 2)==
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<StructureSection load='4a09' size='340' side='right'caption='[[4a09]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4a09]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A09 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4a09]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A09 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TTD:CIS-SYN+CYCLOBUTANE+THYMINE+DIMER'>TTD</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TTD:CIS-SYN+CYCLOBUTANE+THYMINE+DIMER'>TTD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2b5l|2b5l]], [[2b5m|2b5m]], [[2hye|2hye]], [[2b5n|2b5n]], [[4a0a|4a0a]], [[4a0b|4a0b]], [[4a08|4a08]], [[4a0c|4a0c]], [[3ei1|3ei1]], [[3ei2|3ei2]], [[3ei3|3ei3]], [[3ei4|3ei4]], [[4a0l|4a0l]], [[4a11|4a11]], [[4a0k|4a0k]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a09 OCA], [https://pdbe.org/4a09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a09 RCSB], [https://www.ebi.ac.uk/pdbsum/4a09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a09 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a09 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a09 RCSB], [http://www.ebi.ac.uk/pdbsum/4a09 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DDB2_DANRE DDB2_DANRE] Required for DNA repair. Binds to ddb1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex which may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (By similarity).
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4a09" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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[[Category: Danio rerio]]
[[Category: Danio rerio]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fischer, E S]]
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[[Category: Large Structures]]
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[[Category: Gut, H]]
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[[Category: Synthetic construct]]
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[[Category: Iwai, S]]
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[[Category: Fischer ES]]
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[[Category: Scrima, A]]
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[[Category: Gut H]]
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[[Category: Thoma, N H]]
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[[Category: Iwai S]]
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[[Category: Ddb]]
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[[Category: Scrima A]]
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[[Category: Dna damage repair]]
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[[Category: Thoma NH]]
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[[Category: Dna-binding protein-dna complex]]
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Current revision

Structure of hsDDB1-drDDB2 bound to a 15 bp CPD-duplex (purine at D-1 position) at 3.1 A resolution (CPD 2)

PDB ID 4a09

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