4g2b
From Proteopedia
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==Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI== | ==Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI== | ||
| - | <StructureSection load='4g2b' size='340' side='right' caption='[[4g2b]], [[Resolution|resolution]] 2.05Å' scene=''> | + | <StructureSection load='4g2b' size='340' side='right'caption='[[4g2b]], [[Resolution|resolution]] 2.05Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4g2b]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4g2b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G2B FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2b OCA], [https://pdbe.org/4g2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g2b RCSB], [https://www.ebi.ac.uk/pdbsum/4g2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2b ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SSEI_SALTY SSEI_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required to maintain a long-term chronic systemic infection in mice. It inhibits normal cell migration of primary macrophages and dendritic cells, by a mechanism that involves interaction with the host factor IQGAP1, an important regulator of the cytoskeleton and cell migration. Also accelerates the systemic spread of infection from the gastrointestinal tract to the bloodstream, probably by interacting with host TRIP6.<ref>PMID:17095609</ref> <ref>PMID:19956712</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4g2b" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Salmonella enterica subsp. enterica serovar | + | [[Category: Large Structures]] |
| - | [[Category: Bhaskaran | + | [[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]] |
| - | [[Category: Stebbins | + | [[Category: Bhaskaran SS]] |
| - | + | [[Category: Stebbins CE]] | |
| - | + | ||
Current revision
Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI
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