3tfl

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==LytR-Cps2a-Psr family protein with bound octaprenyl pyrophosphate lipid==
==LytR-Cps2a-Psr family protein with bound octaprenyl pyrophosphate lipid==
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<StructureSection load='3tfl' size='340' side='right' caption='[[3tfl]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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<StructureSection load='3tfl' size='340' side='right'caption='[[3tfl]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tfl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TFL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tfl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TFL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZTP:(2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-OCTAMETHYLDOTRIACONTA-2,6,10,14,18,22,26,30-OCTAEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>ZTP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tel|3tel]], [[3tep|3tep]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZTP:(2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-OCTAMETHYLDOTRIACONTA-2,6,10,14,18,22,26,30-OCTAEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>ZTP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPC02_0004, wzg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfl OCA], [https://pdbe.org/3tfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tfl RCSB], [https://www.ebi.ac.uk/pdbsum/3tfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tfl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tfl RCSB], [http://www.ebi.ac.uk/pdbsum/3tfl PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q4K376_STREE Q4K376_STREE]
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Teichoic acids and acidic capsular polysaccharides are major anionic cell wall polymers (APs) in many bacteria, with various critical cell functions, including maintenance of cell shape and structural integrity, charge and cation homeostasis, and multiple aspects of pathogenesis. We have identified the widespread LytR-Cps2A-Psr (LCP) protein family, of previously unknown function, as novel enzymes required for AP synthesis. Structural and biochemical analysis of several LCP proteins suggest that they carry out the final step of transferring APs from their lipid-linked precursor to cell wall peptidoglycan (PG). In Bacillus subtilis, LCP proteins are found in association with the MreB cytoskeleton, suggesting that MreB proteins coordinate the insertion of the major polymers, PG and AP, into the cell wall.
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A widespread family of bacterial cell wall assembly proteins.,Kawai Y, Marles-Wright J, Cleverley RM, Emmins R, Ishikawa S, Kuwano M, Heinz N, Bui NK, Hoyland CN, Ogasawara N, Lewis RJ, Vollmer W, Daniel RA, Errington J EMBO J. 2011 Sep 30. doi: 10.1038/emboj.2011.358. PMID:21964069<ref>PMID:21964069</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
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[[Category: Bui, N Khai]]
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[[Category: Cleverley RM]]
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[[Category: Cleverley, R M]]
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[[Category: Daniel RA]]
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[[Category: Daniel, R A]]
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[[Category: Emmins R]]
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[[Category: Emmins, R]]
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[[Category: Errington J]]
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[[Category: Errington, J]]
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[[Category: Heinz N]]
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[[Category: Heinz, N]]
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[[Category: Hoyland CN]]
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[[Category: Hoyland, C N]]
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[[Category: Ishikawa S]]
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[[Category: Ishikawa, S]]
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[[Category: Kawai Y]]
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[[Category: Kawai, Y]]
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[[Category: Khai Bui N]]
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[[Category: Kuwano, M]]
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[[Category: Kuwano M]]
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[[Category: Lewis, R J]]
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[[Category: Lewis RJ]]
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[[Category: Marles-Wright, J]]
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[[Category: Marles-Wright J]]
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[[Category: Ogasawara, N]]
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[[Category: Ogasawara N]]
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[[Category: Vollmer, W]]
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[[Category: Vollmer W]]
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[[Category: Bacterial cell wall techoic acid synthesis]]
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[[Category: Transferase]]
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Current revision

LytR-Cps2a-Psr family protein with bound octaprenyl pyrophosphate lipid

PDB ID 3tfl

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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