1o7c

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[[Image:1o7c.jpg|left|200px]]
 
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{{Structure
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==Solution structure of the human TSG-6 Link module in the presence of a hyaluronan octasaccharide==
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|PDB= 1o7c |SIZE=350|CAPTION= <scene name='initialview01'>1o7c</scene>
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<StructureSection load='1o7c' size='340' side='right'caption='[[1o7c]]' scene=''>
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|SITE= <scene name='pdbsite=HYA:Hyaluronan-Binding+Site+(Refs+1,+3)'>HYA</scene>
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1o7c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O7C FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7c OCA], [https://pdbe.org/1o7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o7c RCSB], [https://www.ebi.ac.uk/pdbsum/1o7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7c ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''SOLUTION STRUCTURE OF THE HUMAN TSG-6 LINK MODULE IN THE PRESENCE OF A HYALURONAN OCTASACCHARIDE'''
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[https://www.uniprot.org/uniprot/TSG6_HUMAN TSG6_HUMAN] Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The solution structure of the Link module from human TSG-6, a hyaladherin with important roles in inflammation and ovulation, has been determined in both its free and hyaluronan-bound conformations. This reveals a well defined hyaluronan-binding groove on one face of the Link module that is closed in the absence of ligand. The groove is lined with amino acids that have been implicated in mediating the interaction with hyaluronan, including two tyrosine residues that appear to form essential intermolecular hydrogen bonds and two basic residues capable of supporting ionic interactions. This is the first structure of a non-enzymic hyaladherin in its active state, and identifies a ligand-induced conformational change that is likely to be conserved across the Link module superfamily. NMR and isothermal titration calorimetry experiments with defined oligosaccharides have allowed us to infer the minimum length of hyaluronan that can be accommodated within the binding site and its polarity in the groove; these data have been used to generate a model of the complex formed between the Link module and a hyaluronan octasaccharide.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/1o7c_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1O7C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7C OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o7c ConSurf].
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The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding., Blundell CD, Mahoney DJ, Almond A, DeAngelis PL, Kahmann JD, Teriete P, Pickford AR, Campbell ID, Day AJ, J Biol Chem. 2003 Dec 5;278(49):49261-70. Epub 2003 Sep 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12972412 12972412]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Blundell, C D.]]
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[[Category: Blundell CD]]
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[[Category: Campbell, I D.]]
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[[Category: Campbell ID]]
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[[Category: Day, A J.]]
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[[Category: Day AJ]]
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[[Category: Kahmann, J D.]]
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[[Category: Kahmann JD]]
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[[Category: Pickford, A R.]]
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[[Category: Pickford AR]]
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[[Category: Teriete, P.]]
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[[Category: Teriete P]]
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[[Category: carbohydrate-binding domain]]
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[[Category: cell adhesion]]
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[[Category: glycoprotein]]
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[[Category: hyaluronan-binding domain]]
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[[Category: link module]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:06:45 2008''
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Current revision

Solution structure of the human TSG-6 Link module in the presence of a hyaluronan octasaccharide

PDB ID 1o7c

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