4as4
From Proteopedia
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==Structure of human inositol monophosphatase 1== | ==Structure of human inositol monophosphatase 1== | ||
- | <StructureSection load='4as4' size='340' side='right' caption='[[4as4]], [[Resolution|resolution]] 1.70Å' scene=''> | + | <StructureSection load='4as4' size='340' side='right'caption='[[4as4]], [[Resolution|resolution]] 1.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[4as4]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4as4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AS4 FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> |
- | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
- | < | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4as4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4as4 OCA], [https://pdbe.org/4as4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4as4 RCSB], [https://www.ebi.ac.uk/pdbsum/4as4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4as4 ProSAT]</span></td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/IMPA1_HUMAN IMPA1_HUMAN] Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.<ref>PMID:17068342</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
+ | <div class="pdbe-citations 4as4" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
- | *[[Inositol | + | *[[Inositol monophosphatase 3D structures|Inositol monophosphatase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
- | [[Category: | + | [[Category: Large Structures]] |
- | [[Category: Churchill | + | [[Category: Churchill GC]] |
- | [[Category: Halliday | + | [[Category: Halliday AC]] |
- | [[Category: Knight | + | [[Category: Knight M]] |
- | [[Category: Lack | + | [[Category: Lack NA]] |
- | [[Category: Lowe | + | [[Category: Lowe ED]] |
- | [[Category: Singh | + | [[Category: Singh N]] |
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Current revision
Structure of human inositol monophosphatase 1
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Categories: Homo sapiens | Large Structures | Churchill GC | Halliday AC | Knight M | Lack NA | Lowe ED | Singh N