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4gza

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==Complex of mouse Plexin A2 - Semaphorin 3A - Neuropilin-1==
==Complex of mouse Plexin A2 - Semaphorin 3A - Neuropilin-1==
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<StructureSection load='4gza' size='340' side='right' caption='[[4gza]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
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<StructureSection load='4gza' size='340' side='right'caption='[[4gza]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gza]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GZA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gza]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GZA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gz8|4gz8]], [[4gz9|4gz9]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Plxna2, Kiaa0463 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Sema3a, Semad, SemD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Nrp1, Nrp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gza OCA], [https://pdbe.org/4gza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gza RCSB], [https://www.ebi.ac.uk/pdbsum/4gza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gza ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gza RCSB], [http://www.ebi.ac.uk/pdbsum/4gza PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLXA2_MOUSE PLXA2_MOUSE] Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:10520994</ref> <ref>PMID:10781943</ref> <ref>PMID:20877282</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4gza" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
*[[Neuropilin|Neuropilin]]
*[[Neuropilin|Neuropilin]]
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*[[Plexin|Plexin]]
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*[[Plexin 3D structures|Plexin 3D structures]]
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*[[Semaphorin|Semaphorin]]
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*[[Semaphorin 3D structures|Semaphorin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Janssen, B J.C]]
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[[Category: Janssen BJC]]
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[[Category: Jones, E Y]]
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[[Category: Jones EY]]
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[[Category: Malinauskas, T]]
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[[Category: Malinauskas T]]
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[[Category: Siebold, C]]
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[[Category: Siebold C]]
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[[Category: Cell-cell signaling]]
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[[Category: Glycosilation]]
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[[Category: Mammalian]]
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[[Category: Multi-domain]]
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[[Category: Signaling protein]]
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[[Category: Ternary complex]]
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[[Category: Transmembrane]]
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Current revision

Complex of mouse Plexin A2 - Semaphorin 3A - Neuropilin-1

PDB ID 4gza

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