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4hmz

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==Crystal Structure of ChmJ, a 3'-monoepimerase from Streptomyces bikiniensis in complex with dTDP-quinovose==
==Crystal Structure of ChmJ, a 3'-monoepimerase from Streptomyces bikiniensis in complex with dTDP-quinovose==
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<StructureSection load='4hmz' size='340' side='right' caption='[[4hmz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4hmz' size='340' side='right'caption='[[4hmz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hmz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_bikiniensis Streptomyces bikiniensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HMZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hmz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_bikiniensis Streptomyces bikiniensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HMZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=18T:[(2R,3S,5R)-3-HYDROXY-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-YL]METHYL+(2R,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL+DIHYDROGEN+DIPHOSPHATE'>18T</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hn0|4hn0]], [[4hn1|4hn1]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=18T:[(2R,3S,5R)-3-HYDROXY-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-YL]METHYL+(2R,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL+DIHYDROGEN+DIPHOSPHATE'>18T</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">chmJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1896 Streptomyces bikiniensis])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmz OCA], [https://pdbe.org/4hmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hmz RCSB], [https://www.ebi.ac.uk/pdbsum/4hmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hmz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hmz RCSB], [http://www.ebi.ac.uk/pdbsum/4hmz PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CHMJ_STRBI CHMJ_STRBI] Catalyzes the conversion of dTDP-4-oxo-6-deoxyglucose to dTDP-4-oxo-6-deoxyallose, via a C-3 epimerization. This is a step in the biosynthesis of the mycinose moiety of the chalcomycin antibiotic.<ref>PMID:23116432</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4hmz" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces bikiniensis]]
[[Category: Streptomyces bikiniensis]]
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[[Category: Holden, H M]]
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[[Category: Holden HM]]
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[[Category: Kubiak, R L]]
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[[Category: Kubiak RL]]
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[[Category: 3'-monoepimerase]]
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[[Category: Chalcomycin]]
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[[Category: Cupin fold]]
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[[Category: Deoxysugar]]
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[[Category: Dtdp-mycinose]]
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[[Category: Dtdp-quinovose]]
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[[Category: Epimerization]]
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[[Category: Natural product]]
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[[Category: Nucleotide-linked sugar]]
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[[Category: Unknown function]]
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Current revision

Crystal Structure of ChmJ, a 3'-monoepimerase from Streptomyces bikiniensis in complex with dTDP-quinovose

PDB ID 4hmz

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