4hac

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==Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei==
==Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei==
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<StructureSection load='4hac' size='340' side='right' caption='[[4hac]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
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<StructureSection load='4hac' size='340' side='right'caption='[[4hac]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hac]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_mazei_go1 Methanosarcina mazei go1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HAC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hac]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_mazei_Go1 Methanosarcina mazei Go1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HAC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MM_1762, MVK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=192952 Methanosarcina mazei Go1])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hac OCA], [https://pdbe.org/4hac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hac RCSB], [https://www.ebi.ac.uk/pdbsum/4hac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hac ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mevalonate_kinase Mevalonate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.36 2.7.1.36] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hac RCSB], [http://www.ebi.ac.uk/pdbsum/4hac PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8PW39_METMA Q8PW39_METMA] Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.[HAMAP-Rule:MF_00217]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4hac" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Mevalonate kinase|Mevalonate kinase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Methanosarcina mazei go1]]
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[[Category: Large Structures]]
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[[Category: Mevalonate kinase]]
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[[Category: Methanosarcina mazei Go1]]
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[[Category: Lee, K H]]
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[[Category: Lee KH]]
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[[Category: Zhuang, N]]
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[[Category: Zhuang N]]
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[[Category: Atp binding]]
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[[Category: Ghmp]]
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[[Category: Phosphorylation]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei

PDB ID 4hac

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