4ghu
From Proteopedia
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==Crystal structure of TRAF3/Cardif== | ==Crystal structure of TRAF3/Cardif== | ||
| - | <StructureSection load='4ghu' size='340' side='right' caption='[[4ghu]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='4ghu' size='340' side='right'caption='[[4ghu]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4ghu]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4ghu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GHU FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.199Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ghu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ghu OCA], [https://pdbe.org/4ghu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ghu RCSB], [https://www.ebi.ac.uk/pdbsum/4ghu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ghu ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRAF3_MOUSE TRAF3_MOUSE] Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.<ref>PMID:16306936</ref> <ref>PMID:16306937</ref> <ref>PMID:17015635</ref> <ref>PMID:17158868</ref> <ref>PMID:18313334</ref> <ref>PMID:18997792</ref> <ref>PMID:18997794</ref> <ref>PMID:19228877</ref> <ref>PMID:19898473</ref> <ref>PMID:8934568</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4ghu" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Zhang | + | [[Category: Zhang P]] |
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Current revision
Crystal structure of TRAF3/Cardif
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