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4gao
From Proteopedia
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==DCNL complex with N-terminally acetylated NEDD8 E2 peptide== | ==DCNL complex with N-terminally acetylated NEDD8 E2 peptide== | ||
| - | <StructureSection load='4gao' size='340' side='right' caption='[[4gao]], [[Resolution|resolution]] 3.28Å' scene=''> | + | <StructureSection load='4gao' size='340' side='right'caption='[[4gao]], [[Resolution|resolution]] 3.28Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4gao]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4gao]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAO FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.28Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AME:N-ACETYLMETHIONINE'>AME</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gao OCA], [https://pdbe.org/4gao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gao RCSB], [https://www.ebi.ac.uk/pdbsum/4gao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gao ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DCNL2_HUMAN DCNL2_HUMAN] Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.<ref>PMID:23201271</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4gao" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Bennett EJ]] |
| - | [[Category: | + | [[Category: Harper JW]] |
| - | [[Category: | + | [[Category: Miller DJ]] |
| - | [[Category: | + | [[Category: Monda JK]] |
| - | [[Category: | + | [[Category: Schulman BA]] |
| - | [[Category: | + | [[Category: Scott DC]] |
| - | + | ||
Current revision
DCNL complex with N-terminally acetylated NEDD8 E2 peptide
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