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4omt

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==Crystal structure of human muscle phosphofructokinase (dissociated homodimer)==
==Crystal structure of human muscle phosphofructokinase (dissociated homodimer)==
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<StructureSection load='4omt' size='340' side='right' caption='[[4omt]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
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<StructureSection load='4omt' size='340' side='right'caption='[[4omt]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4omt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OMT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4omt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OMT FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3o8n|3o8n]], [[3opy|3opy]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 6&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4omt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4omt OCA], [https://pdbe.org/4omt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4omt RCSB], [https://www.ebi.ac.uk/pdbsum/4omt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4omt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4omt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4omt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4omt RCSB], [http://www.ebi.ac.uk/pdbsum/4omt PDBsum]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/K6PF_HUMAN K6PF_HUMAN]] Glycogen storage disease due to muscle phosphofructokinase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/PFKAM_HUMAN PFKAM_HUMAN] Glycogen storage disease due to muscle phosphofructokinase deficiency. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/K6PF_HUMAN K6PF_HUMAN]] Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.[HAMAP-Rule:MF_00339]
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[https://www.uniprot.org/uniprot/PFKAM_HUMAN PFKAM_HUMAN] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4omt" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphofructokinase 3D structures|Phosphofructokinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 6-phosphofructokinase]]
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[[Category: Homo sapiens]]
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[[Category: Kloos, M]]
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[[Category: Large Structures]]
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[[Category: Straeter, N]]
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[[Category: Kloos M]]
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[[Category: 6-phosphofructokinase activity]]
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[[Category: Straeter N]]
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[[Category: Fructose 6-phosphate]]
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[[Category: Human 6-phosphofructokinase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human muscle phosphofructokinase (dissociated homodimer)

PDB ID 4omt

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