4rg7
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of APC3== | |
| - | + | <StructureSection load='4rg7' size='340' side='right'caption='[[4rg7]], [[Resolution|resolution]] 4.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4rg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RG7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.25Å</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg7 OCA], [https://pdbe.org/4rg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rg7 RCSB], [https://www.ebi.ac.uk/pdbsum/4rg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rg7 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CDC27_HUMAN CDC27_HUMAN] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:18485873</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Miller DJ]] | ||
| + | [[Category: Schulman BA]] | ||
| + | [[Category: Yamaguchi M]] | ||
| + | [[Category: Yu S]] | ||
Current revision
Crystal structure of APC3
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