4x3f

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(New page: '''Unreleased structure''' The entry 4x3f is ON HOLD until Paper Publication Authors: Wagner, T., Wehenkel, A., Alzari, P.M., Bellinzoni, M. Description: Crystal structure of the intra...)
Current revision (10:46, 10 January 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4x3f is ON HOLD until Paper Publication
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==Crystal structure of the intracellular domain of the M. tuberculosis Ser/Thr kinase PknA==
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<StructureSection load='4x3f' size='340' side='right'caption='[[4x3f]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4x3f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X3F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x3f OCA], [https://pdbe.org/4x3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x3f RCSB], [https://www.ebi.ac.uk/pdbsum/4x3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x3f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PKNA_MYCTU PKNA_MYCTU] Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422. Shows a strong preference for Thr versus Ser as the phosphoacceptor.<ref>PMID:15985609</ref> <ref>PMID:16817899</ref> <ref>PMID:19121323</ref> <ref>PMID:20066037</ref> <ref>PMID:21190553</ref> <ref>PMID:21423706</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Signal transduction mediated by Ser/Thr phosphorylation in Mycobacterium tuberculosis has been intensively studied in the last years, as its genome harbors eleven genes coding for eukaryotic-like Ser/Thr kinases. Here we describe the crystal structure and the autophosphorylation sites of the catalytic domain of PknA, one of two protein kinases essential for pathogen's survival. The structure of the ligand-free kinase domain shows an auto-inhibited conformation similar to that observed in human Tyr kinases of the Src-family. These results reinforce the high conservation of structural hallmarks and regulation mechanisms between prokaryotic and eukaryotic protein kinases. This article is protected by copyright. All rights reserved.
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Authors: Wagner, T., Wehenkel, A., Alzari, P.M., Bellinzoni, M.
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The crystal structure of the catalytic domain of the Ser/Thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.,Wagner T, Alexandre M, Duran R, Barilone N, Wehenkel A, Alzari PM, Bellinzoni M Proteins. 2015 Jan 13. doi: 10.1002/prot.24754. PMID:25586004<ref>PMID:25586004</ref>
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Description: Crystal structure of the intracellular domain of the M. tuberculosis Ser/Thr kinase PknA
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4x3f" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Alzari PM]]
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[[Category: Bellinzoni M]]
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[[Category: Wagner T]]
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[[Category: Wehenkel A]]

Current revision

Crystal structure of the intracellular domain of the M. tuberculosis Ser/Thr kinase PknA

PDB ID 4x3f

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