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1oni

From Proteopedia

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[[Image:1oni.gif|left|200px]]
 
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{{Structure
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==Crystal structure of a human p14.5, a translational inhibitor reveals different mode of ligand binding near the invariant residues of the Yjgf/UK114 protein family==
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|PDB= 1oni |SIZE=350|CAPTION= <scene name='initialview01'>1oni</scene>, resolution 1.90&Aring;
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<StructureSection load='1oni' size='340' side='right'caption='[[1oni]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=BEZ:BENZOIC ACID'>BEZ</scene>
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<table><tr><td colspan='2'>[[1oni]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ONI FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE= PSP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oni OCA], [https://pdbe.org/1oni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oni RCSB], [https://www.ebi.ac.uk/pdbsum/1oni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oni ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of a human p14.5, a translational inhibitor reveals different mode of ligand binding near the invariant residues of the Yjgf/UK114 protein family'''
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== Function ==
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[https://www.uniprot.org/uniprot/RIDA_HUMAN RIDA_HUMAN] Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.<ref>PMID:20817725</ref> <ref>PMID:22094463</ref> Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex (PubMed:8973653, PubMed:30930054). Acts by bridging YTHDF2 and the ribonuclease P/MRP complex (PubMed:30930054). RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage (PubMed:30930054).<ref>PMID:30930054</ref> <ref>PMID:8973653</ref>
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== Evolutionary Conservation ==
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==Disease==
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[[Image:Consurf_key_small.gif|200px|right]]
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Known disease associated with this structure: Phosphoserine phosphatase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=172480 172480]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/1oni_consurf.spt"</scriptWhenChecked>
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1ONI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONI OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of Homo sapiens protein hp14.5., Manjasetty BA, Delbruck H, Pham DT, Mueller U, Fieber-Erdmann M, Scheich C, Sievert V, Bussow K, Niesen FH, Weihofen W, Loll B, Saenger W, Heinemann U, Proteins. 2004 Mar 1;54(4):797-800. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14997576 14997576]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oni ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Delbrueck, H.]]
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[[Category: Delbrueck H]]
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[[Category: Erdmann, M F.]]
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[[Category: Erdmann MF]]
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[[Category: Heinemann, U.]]
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[[Category: Heinemann U]]
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[[Category: Manjasetty, B A.]]
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[[Category: Manjasetty BA]]
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[[Category: Mueller, U.]]
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[[Category: Mueller U]]
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[[Category: BEZ]]
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[[Category: translational inhibitor]]
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[[Category: trichloroacetic acid soluble protein]]
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[[Category: yjgf/yer057c/uk114 family]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:13:11 2008''
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Current revision

Crystal structure of a human p14.5, a translational inhibitor reveals different mode of ligand binding near the invariant residues of the Yjgf/UK114 protein family

PDB ID 1oni

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