1onk

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[[Image:1onk.gif|left|200px]]
 
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{{Structure
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==Mistletoe lectin I from viscum album==
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|PDB= 1onk |SIZE=350|CAPTION= <scene name='initialview01'>1onk</scene>, resolution 2.10&Aring;
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<StructureSection load='1onk' size='340' side='right'caption='[[1onk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[1onk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ONK FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1onk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1onk OCA], [https://pdbe.org/1onk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1onk RCSB], [https://www.ebi.ac.uk/pdbsum/1onk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1onk ProSAT]</span></td></tr>
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</table>
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'''Mistletoe lectin I from viscum album'''
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== Function ==
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[https://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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1ONK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONK OCA].
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Check<jmol>
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[[Category: Protein complex]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/1onk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1onk ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Viscum album]]
[[Category: Viscum album]]
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[[Category: rRNA N-glycosylase]]
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[[Category: Betzel C]]
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[[Category: Betzel, C.]]
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[[Category: Gabdoulkhakov AG]]
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[[Category: Gabdoulkhakov, A G.]]
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[[Category: Konareva N]]
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[[Category: Konareva, N.]]
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[[Category: Kornev AN]]
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[[Category: Kornev, A N.]]
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[[Category: Kornilov V]]
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[[Category: Kornilov, V.]]
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[[Category: Krauspenhaar R]]
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[[Category: Krauspenhaar, R.]]
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[[Category: Mikhailov AM]]
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[[Category: Mikhailov, A M.]]
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[[Category: Nikonov SV]]
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[[Category: Nikonov, S V.]]
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[[Category: Savoshkina Y]]
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[[Category: Savoshkina, Y.]]
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[[Category: Stoeva S]]
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[[Category: Stoeva, S.]]
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[[Category: Voelter W]]
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[[Category: Voelter, W.]]
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[[Category: AZI]]
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[[Category: GOL]]
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[[Category: NAG]]
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[[Category: PO4]]
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[[Category: ribosome-inactivating protein type ii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:13:17 2008''
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Current revision

Mistletoe lectin I from viscum album

PDB ID 1onk

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OCA

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