4o6o
From Proteopedia
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==Structural and functional studies the characterization of Cys4 Zinc-finger motif in the recombination mediator protein RecR== | ==Structural and functional studies the characterization of Cys4 Zinc-finger motif in the recombination mediator protein RecR== | ||
| - | <StructureSection load='4o6o' size='340' side='right' caption='[[4o6o]], [[Resolution|resolution]] 3.00Å' scene=''> | + | <StructureSection load='4o6o' size='340' side='right'caption='[[4o6o]], [[Resolution|resolution]] 3.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4o6o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6O OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4o6o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis_MB4 Caldanaerobacter subterraneus subsp. tengcongensis MB4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O6O FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6o OCA], [https://pdbe.org/4o6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o6o RCSB], [https://www.ebi.ac.uk/pdbsum/4o6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6o ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RECR_CALS4 RECR_CALS4] May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.[HAMAP-Rule:MF_00017] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Zinc finger motif widely exists in protein structure, which can play different roles in different proteins. RecR is an important recombination mediator protein (RMP) in the RecFOR pathway and zinc finger motif is the most conserved domain in RecR protein. However, the function of this zinc finger motif in RecR is unclear. Here, we have studied the structures of the single cysteine and double cysteines mutation within the zinc finger motif in Thermoanaerobacter tengcongensis RecR (TTERecR). We have also studied the DNA binding ability as well as TTERecO protein binding ability of single, double and even triple cysteines mutation of the zinc finger motif, and the mutants do not alter DNA binding by RecR nor the interaction between RecR and RecO. The function of TTERecR zinc finger motif is to maintain the stability of the three-dimensional structure. | ||
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| + | Structural and functional characterization of Cys4 zinc finger motif in the recombination mediator protein RecR.,Tang Q, Liu YP, Yan XX, Liang DC DNA Repair (Amst). 2014 Dec;24:10-14. doi: 10.1016/j.dnarep.2014.09.012. PMID:25460918<ref>PMID:25460918</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4o6o" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Caldanaerobacter subterraneus subsp. tengcongensis MB4]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Liang DC]] |
| - | [[Category: | + | [[Category: Liu YP]] |
| - | [[Category: | + | [[Category: Tang Q]] |
| - | [[Category: | + | [[Category: Yan XX]] |
| - | + | ||
| - | + | ||
Current revision
Structural and functional studies the characterization of Cys4 Zinc-finger motif in the recombination mediator protein RecR
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