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4ix2

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==Inosine 5'-monophosphate dehydrogenase from Vibrio cholerae, deletion mutant, complexed with IMP==
==Inosine 5'-monophosphate dehydrogenase from Vibrio cholerae, deletion mutant, complexed with IMP==
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<StructureSection load='4ix2' size='340' side='right' caption='[[4ix2]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='4ix2' size='340' side='right'caption='[[4ix2]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ix2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae_o1_biovar_el_tor_str._n16961 Vibrio cholerae o1 biovar el tor str. n16961]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ff0 4ff0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IX2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ix2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ff0 4ff0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IX2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.146&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fxs|4fxs]], [[4fez|4fez]], [[4fo4|4fo4]], [[4hlv|4hlv]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">guaB, VC0767, VC_0767 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243277 Vibrio cholerae O1 biovar El Tor str. N16961])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ix2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ix2 OCA], [https://pdbe.org/4ix2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ix2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ix2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ix2 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ix2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ix2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ix2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ix2 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9KTW3_VIBCH Q9KTW3_VIBCH] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]
==See Also==
==See Also==
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*[[Inosine monophosphate dehydrogenase|Inosine monophosphate dehydrogenase]]
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*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: IMP dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Vibrio cholerae o1 biovar el tor str. n16961]]
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[[Category: Vibrio cholerae O1 biovar El Tor str. N16961]]
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[[Category: Anderson, W F]]
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[[Category: Anderson WF]]
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[[Category: Structural genomic]]
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[[Category: Gu M]]
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[[Category: Gu, M]]
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[[Category: Joachimiak A]]
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[[Category: Joachimiak, A]]
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[[Category: Makowska-Grzyska M]]
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[[Category: Makowska-Grzyska, M]]
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[[Category: Maltseva N]]
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[[Category: Maltseva, N]]
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[[Category: Osipiuk J]]
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[[Category: Osipiuk, J]]
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[[Category: Csgid]]
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[[Category: Imp]]
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[[Category: Impdh]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Oxidoreductase]]
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Current revision

Inosine 5'-monophosphate dehydrogenase from Vibrio cholerae, deletion mutant, complexed with IMP

PDB ID 4ix2

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