4i0k
From Proteopedia
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==Crystal structure of murine B7-H3 extracellular domain== | ==Crystal structure of murine B7-H3 extracellular domain== | ||
| - | <StructureSection load='4i0k' size='340' side='right' caption='[[4i0k]], [[Resolution|resolution]] 2.97Å' scene=''> | + | <StructureSection load='4i0k' size='340' side='right'caption='[[4i0k]], [[Resolution|resolution]] 2.97Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4i0k]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4i0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I0K FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand= | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.97Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i0k OCA], [https://pdbe.org/4i0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i0k RCSB], [https://www.ebi.ac.uk/pdbsum/4i0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i0k ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CD276_MOUSE CD276_MOUSE] Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. Plays a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells.<ref>PMID:12055244</ref> <ref>PMID:12925852</ref> <ref>PMID:12939639</ref> <ref>PMID:15294965</ref> <ref>PMID:15682454</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | T cell activity is controlled by a combination of antigen-dependent signaling through the T cell receptor and a set of auxiliary signals delivered through antigen-independent interactions, including the recognition of the B7 family of ligands. B7-H3 is a recently identified B7 family member that is strongly overexpressed in a range of cancers and correlates with poor prognosis. We report the crystal structure of murine B7-H3 at a 3 A resolution, which provides a model for the organization of the IgV and IgC domains within the ectodomain. We demonstrate that B7-H3 inhibits T cell proliferation and show that the FG loop of the IgV domain plays a critical role in this function. B7-H3 crystallized as an unusual dimer arising from the exchange of the G strands in the IgV domains of partner molecules. This arrangement, in combination with previous reports, highlights the dynamic nature and plasticity of the immunoglobulin fold. | ||
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| + | Structure and T cell inhibition properties of B7 family member, B7-H3.,Vigdorovich V, Ramagopal UA, Lazar-Molnar E, Sylvestre E, Lee JS, Hofmeyer KA, Zang X, Nathenson SG, Almo SC Structure. 2013 May 7;21(5):707-17. doi: 10.1016/j.str.2013.03.003. Epub 2013 Apr, 11. PMID:23583036<ref>PMID:23583036</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4i0k" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Almo | + | [[Category: Almo SC]] |
| - | [[Category: Bonanno | + | [[Category: Bonanno JB]] |
| - | + | [[Category: Nathenson SG]] | |
| - | + | [[Category: Ramagopal U]] | |
| - | [[Category: Nathenson | + | [[Category: Toro R]] |
| - | [[Category: Ramagopal | + | [[Category: Vigdorovich V]] |
| - | [[Category: Toro | + | |
| - | [[Category: Vigdorovich | + | |
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Current revision
Crystal structure of murine B7-H3 extracellular domain
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