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4imv

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==Ricin A-chain variant 1-33/44-198 with engineered disulfide bond, R48C/T77C/D75N==
==Ricin A-chain variant 1-33/44-198 with engineered disulfide bond, R48C/T77C/D75N==
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<StructureSection load='4imv' size='340' side='right' caption='[[4imv]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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<StructureSection load='4imv' size='340' side='right'caption='[[4imv]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4imv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IMV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4imv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. The May 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ricin'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_5 10.2210/rcsb_pdb/mom_2013_5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IMV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lc9|3lc9]], [[3mk9|3mk9]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4imv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imv OCA], [https://pdbe.org/4imv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4imv RCSB], [https://www.ebi.ac.uk/pdbsum/4imv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4imv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4imv RCSB], [http://www.ebi.ac.uk/pdbsum/4imv PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4imv" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Ricin|Ricin]]
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*[[Ricin 3D structures|Ricin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ricinus communis]]
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[[Category: Large Structures]]
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[[Category: RRNA N-glycosylase]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Compton, J R]]
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[[Category: Legler, P M]]
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[[Category: Millard, C B]]
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[[Category: Hydrolase]]
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[[Category: Immunogen]]
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[[Category: Ricin]]
[[Category: Ricin]]
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[[Category: Thermal stable]]
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[[Category: Ricinus communis]]
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[[Category: Vaccine]]
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[[Category: Compton JR]]
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[[Category: Legler PM]]
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[[Category: Millard CB]]

Current revision

Ricin A-chain variant 1-33/44-198 with engineered disulfide bond, R48C/T77C/D75N

PDB ID 4imv

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