4ii1
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of the zinc finger of ZGPAT== | ==Crystal structure of the zinc finger of ZGPAT== | ||
| - | <StructureSection load='4ii1' size='340' side='right' caption='[[4ii1]], [[Resolution|resolution]] 2.65Å' scene=''> | + | <StructureSection load='4ii1' size='340' side='right'caption='[[4ii1]], [[Resolution|resolution]] 2.65Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4ii1]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4ii1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4II1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4II1 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ii1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ii1 OCA], [https://pdbe.org/4ii1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ii1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ii1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ii1 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZGPAT_HUMAN ZGPAT_HUMAN] Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.<ref>PMID:19644445</ref> Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.<ref>PMID:19644445</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Bian | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bian C]] |
| - | [[Category: Chao | + | [[Category: Bountra C]] |
| - | [[Category: Dong | + | [[Category: Chao X]] |
| - | [[Category: Edwards | + | [[Category: Dong A]] |
| - | [[Category: Fu | + | [[Category: Edwards AM]] |
| - | [[Category: Min | + | [[Category: Fu M]] |
| - | + | [[Category: Min J]] | |
| - | [[Category: Tempel | + | [[Category: Tempel W]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Wernimont | + | [[Category: Wernimont AK]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of the zinc finger of ZGPAT
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bian C | Bountra C | Chao X | Dong A | Edwards AM | Fu M | Min J | Tempel W | Weigelt J | Wernimont AK
