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4iua
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==Crystal Structure of the NK2 Fragment (31-290) of the mouse Hepatocyte Growth Factor/Scatter Factor== | ==Crystal Structure of the NK2 Fragment (31-290) of the mouse Hepatocyte Growth Factor/Scatter Factor== | ||
| - | <StructureSection load='4iua' size='340' side='right' caption='[[4iua]], [[Resolution|resolution]] 3.05Å' scene=''> | + | <StructureSection load='4iua' size='340' side='right'caption='[[4iua]], [[Resolution|resolution]] 3.05Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4iua]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4iua]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IUA FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | < | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iua OCA], [https://pdbe.org/4iua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iua RCSB], [https://www.ebi.ac.uk/pdbsum/4iua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iua ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HGF_MOUSE HGF_MOUSE] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:20624990</ref> | ||
==See Also== | ==See Also== | ||
*[[Hepatocyte growth factor|Hepatocyte growth factor]] | *[[Hepatocyte growth factor|Hepatocyte growth factor]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Kovach | + | [[Category: Kovach A]] |
| - | [[Category: Melcher | + | [[Category: Melcher K]] |
| - | [[Category: Tolbert | + | [[Category: Tolbert WD]] |
| - | [[Category: Xu | + | [[Category: Xu HE]] |
| - | [[Category: Zhou | + | [[Category: Zhou E]] |
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Current revision
Crystal Structure of the NK2 Fragment (31-290) of the mouse Hepatocyte Growth Factor/Scatter Factor
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Categories: Large Structures | Mus musculus | Kovach A | Melcher K | Tolbert WD | Xu HE | Zhou E
