Tissue factor
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Structure of human tissue factor (green) complex with coagulation factor VIIa heavy chain (magenta) and light chain (deep sky blue) and Ca+2 ion (green) (PDB code [[1j9c]]).' scene='59/595166/Cv/1'> |
== Function == | == Function == | ||
| - | '''Tissue factor''' (TF) is a high-affinity receptor for the blood coagulation factor VII. The TF/factor VII complex is responsible for the initiation of the coagulation protease cascade. | + | '''Tissue factor''' (TF) is a high-affinity receptor for the blood coagulation factor VII. The TF/factor VII complex is responsible for the initiation of the coagulation protease cascade<ref>PMID:23809131</ref>. |
== Disease == | == Disease == | ||
| - | + | TF is involved in cancer angiogenesis and metastasis<ref>PMID:14614019</ref>. | |
== Relevance == | == Relevance == | ||
| - | + | TF expression by cardiac myocytes is important to maintain heart hemostasis under normal and pathologic conditions<ref>PMID:17663739</ref>. | |
| - | = | + | *<scene name='59/595166/Cv/3'>Human tissue factor complex with coagulation factor VIIa heavy chain, light chain and Ca+2 ion</scene> (PDB code [[1j9c]]). |
</StructureSection> | </StructureSection> | ||
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*Tissue factor | *Tissue factor | ||
| + | **[[2hft]], [[1boy]], [[1tfh]] – hTF extracellular domain – human<br /> | ||
**[[1a21]] – rTF extracellular domain – rabbit<br /> | **[[1a21]] – rTF extracellular domain – rabbit<br /> | ||
| - | **[[2hft]], [[1boy]], [[1tfh]] – hTF extracellular domain – human<br /> | ||
*Tissue factor binary complex | *Tissue factor binary complex | ||
| - | **[[1dan]], [[1j9c]], [[1w0y]] – hTF extracellular domain + factor VIIA<br /> | + | **[[1dan]], [[1j9c]], [[1w0y]], [[4ylq]], [[4z6a]], [[4zma]], [[6r2w]] – hTF extracellular domain + factor VIIA<br /> |
**[[1o5d]] – hTF extracellular domain (mutant) + factor VIIA<br /> | **[[1o5d]] – hTF extracellular domain (mutant) + factor VIIA<br /> | ||
| - | **[[1ahw]], [[1jps]], [[1uj3]] – hTF extracellular domain + antibody<br /> | + | **[[1ahw]], [[1jps]], [[1uj3]], [[4m7l]], [[5w06]] – hTF extracellular domain + antibody<br /> |
*Tissue factor ternary complex with coagulation factor VIIa and inhibitor | *Tissue factor ternary complex with coagulation factor VIIa and inhibitor | ||
Current revision
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3D structures of tissue factor
Updated on 26-February-2020
References
- ↑ Chen VM, Hogg PJ. Encryption and decryption of tissue factor. J Thromb Haemost. 2013 Jun;11 Suppl 1:277-84. doi: 10.1111/jth.12228. PMID:23809131 doi:http://dx.doi.org/10.1111/jth.12228
- ↑ Poon RT, Lau CP, Ho JW, Yu WC, Fan ST, Wong J. Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma. Clin Cancer Res. 2003 Nov 1;9(14):5339-45. PMID:14614019
- ↑ Pawlinski R, Tencati M, Holscher T, Pedersen B, Voet T, Tilley RE, Marynen P, Mackman N. Role of cardiac myocyte tissue factor in heart hemostasis. J Thromb Haemost. 2007 Aug;5(8):1693-700. PMID:17663739 doi:http://dx.doi.org/10.1111/j.1538-7836.2007.02649.x
