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Trypanothione reductase
From Proteopedia
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| - | + | <StructureSection load='' size='350' side='right' caption='Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione and NADPH [[4adw]]' scene='48/489332/Cv/1' pspeed='8'> | |
| + | == Function == | ||
| + | '''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor<ref>PMID:1957352</ref>. | ||
| - | + | == Relevance == | |
| - | + | TTR is found only in parasitic protozoa, hence its inhibitors are used as effective drugs against diseases like Chagas Disease caused by the parasites Trypanosoma and Leishmania<ref>PMID:12769656</ref>. | |
| - | + | ||
| - | + | == Structural highlights == | |
| - | + | The <scene name='48/489332/Cv/6'>active site of TTR</scene> contains <scene name='48/489332/Cv/7'>two catalytic cysteine</scene> residues which are part of the electron transfer function of the enzyme and the bound TPT substrate<ref>PMID:23733388</ref>. | |
| - | + | ||
| + | </StructureSection> | ||
==3D structures of trypanothione reductase== | ==3D structures of trypanothione reductase== | ||
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**[[1gxf]] - TcTTR + inhibitor<br /> | **[[1gxf]] - TcTTR + inhibitor<br /> | ||
**[[2wba]], [[2wov]] - TbTTR + NADPH <br /> | **[[2wba]], [[2wov]] - TbTTR + NADPH <br /> | ||
| - | **[[2wp5]], [[2wp6]], [[2wpc]], [[2wpe]], [[2wpf]], [[4nev]] - TbTTR + inhibitor<br /> | + | **[[5smj]] - TbTTR + FAD<br /> |
| + | **[[2wp5]], [[2wp6]], [[2wpc]], [[2wpe]], [[2wpf]], [[4nev]], [[4new]], [[6btl]], [[6bu7]] - TbTTR + inhibitor<br /> | ||
*Trypanothione reductase ternary complex | *Trypanothione reductase ternary complex | ||
**[[2w0h]], [[2x50]] - LiTTR + NADPH + metal ion<br /> | **[[2w0h]], [[2x50]] - LiTTR + NADPH + metal ion<br /> | ||
| - | **[[2yau]] | + | **[[2yau]], [[4apn]], [[5ebk]] - LiTTR + NADPH + inhibitor<br /> |
| - | + | ||
**[[4adw]] - LiTTR + NADPH + TPT<br /> | **[[4adw]] - LiTTR + NADPH + TPT<br /> | ||
| - | **[[ | + | **[[6er5]], [[6i7n]], [[6t95]], [[6t98]], [[6t97]] - LiTTR + inhibitor + FAD<br /> |
| - | + | **[[2wow]] - TbTTR + NADPH + TPT + inhibitor<BR /> | |
| + | **[[5s9s]], [[5s9t]], [[5s9u]], [[5s9v]], [[5s9w]], [[5s9x]], [[5s9y]], [[5s9z]], [[5sa0]], [[5sa1]], [[5sa2]], [[5sa3]], [[6buz]], [[6btl]], [[6oex]], [[6oey]], [[6oez]], [[6rb5]], [[7nvp]] - TbTTR + inhibitor + FAD<br /> | ||
**[[1typ]] – CfTTR + NADP + TPT<BR /> | **[[1typ]] – CfTTR + NADP + TPT<BR /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Current revision
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3D structures of trypanothione reductase
Updated on 24-January-2024
References
- ↑ Walsh C, Bradley M, Nadeau K. Molecular studies on trypanothione reductase, a target for antiparasitic drugs. Trends Biochem Sci. 1991 Aug;16(8):305-9. PMID:1957352
- ↑ Rivarola HW, Paglini-Oliva PA. Trypanosoma cruzi trypanothione reductase inhibitors: phenothiazines and related compounds modify experimental Chagas' disease evolution. Curr Drug Targets Cardiovasc Haematol Disord. 2002 Jun;2(1):43-52. PMID:12769656
- ↑ Baiocco P, Poce G, Alfonso S, Cocozza M, Porretta GC, Colotti G, Biava M, Moraca F, Botta M, Yardley V, Fiorillo A, Lantella A, Malatesta F, Ilari A. Inhibition of Leishmania infantum Trypanothione Reductase by Azole-Based Compounds: a Comparative Analysis with Its Physiological Substrate by X-ray Crystallography. ChemMedChem. 2013 Jun 3. doi: 10.1002/cmdc.201300176. PMID:23733388 doi:10.1002/cmdc.201300176
