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Tumor necrosis factor

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<StructureSection load='2az5' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene=''>
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<StructureSection load='' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'>
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== Function ==
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'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). See also [[TRAIL]] and [[Molecular Playground/TRAIL]].
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'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNF alpha converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]).
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== Relevance ==
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</StructureSection>
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TNF is studied as both a target and a therapeutic in malignant diseases<ref>PMID:19343034</ref>.
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== 3D Structures of tumor necrosis factor ==
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== Structural highlights ==
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The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/4'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/5'>Inhibitor binding site</scene>.
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*TNF alpha
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== 3D Structures of tumor necrosis factor ==
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**[[1tnf]] – hTNF – human <BR />
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[[Tumor necrosis factor 3D structures]]
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**[[2tun]], [[1a8m]], [[4tsv]], [[5tsw]], [[2e7e]], [[2zjc]], [[2zpx]] – hTNF (mutant) <BR />
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**[[2tnf]] – TNF – mouse <BR />
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**[[2az5]] – hTNF + inhibitor <BR />
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**[[3it8]] – hTNF + poxvirus 2L protein <BR />
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**[[3l9j]] – hTNF + antagonist <BR />
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**[[3alq]] – hTNF (mutant) + TNF receptor <BR />
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**[[4g3y]], [[3wd5]] – hTNF + antibody <BR />
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*TNF beta
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== References ==
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<references/>
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**[[1tnr]] – hTNF + TNF receptor p55 <BR />
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</StructureSection>
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*TNF
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**[[2vfj]] – hTNF ovarian tumor domain <BR />
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}}
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry 2az5)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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