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4v04

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==FGFR1 in complex with ponatinib.==
==FGFR1 in complex with ponatinib.==
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<StructureSection load='4v04' size='340' side='right' caption='[[4v04]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
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<StructureSection load='4v04' size='340' side='right'caption='[[4v04]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4v04]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V04 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4v04]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V04 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4v01|4v01]], [[4v05|4v05]], [[4uxq|4uxq]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v04 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v04 RCSB], [http://www.ebi.ac.uk/pdbsum/4v04 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v04 OCA], [https://pdbe.org/4v04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v04 RCSB], [https://www.ebi.ac.uk/pdbsum/4v04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v04 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D3DSX2_HUMAN D3DSX2_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4v04" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Breed, J]]
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[[Category: Homo sapiens]]
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[[Category: Breeze, A]]
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[[Category: Large Structures]]
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[[Category: Klein, T]]
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[[Category: Breed J]]
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[[Category: Norman, R A]]
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[[Category: Breeze A]]
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[[Category: Overman, R]]
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[[Category: Klein T]]
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[[Category: Phillips, C]]
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[[Category: Norman RA]]
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[[Category: Tucker, J]]
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[[Category: Overman R]]
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[[Category: Transferase]]
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[[Category: Phillips C]]
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[[Category: Tucker J]]

Current revision

FGFR1 in complex with ponatinib.

PDB ID 4v04

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