UvrABC
From Proteopedia
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- | + | <StructureSection load='3pih' size='340' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='53/536710/Cv/3' > | |
+ | == Function == | ||
+ | '''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br /> | ||
+ | * '''UvrA''' is the protein which locates the DNA damage<ref>PMID:21240268</ref>.<br /> | ||
+ | * '''UvrB''' is involved in distinguishing damaged from undamaged DNA<ref>PMID:10946234</ref>.<br /> | ||
+ | * The C-terminal region of '''UvrC''' is involved in DNA binding and incisions at the 5'-side of a DNA damage during nucleotide excision repair<ref>PMID:9421501</ref>. | ||
+ | * '''UvrD''' is '''DNA helicase II'''. See [[Helicase]]. | ||
- | + | For details on the UvrA-UvrB complex see [[UvrA-UvrB interaction domains]]. | |
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+ | == Structural highlights == | ||
+ | UvrA contains several domains: <scene name='53/536710/Cv/2'>UvrB-binding, DNA-binding and two ATP-binding domains</scene><ref>PMID:21240268</ref>. | ||
==3D structures of UvrABC== | ==3D structures of UvrABC== | ||
- | + | [[UvrABC 3D structures]] | |
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- | + | ==References== | |
- | + | <references /> | |
- | + | </StructureSection> | |
[[Category:Topic Page]] | [[Category:Topic Page]] |
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