Variable lymphocyte receptor

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:40, 25 March 2020) (edit) (undo)
 
(19 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3g39| PDB=3g39 | SIZE=400| SCENE= |right| CAPTION=Sea lamprey variable lymphocyte receptor leucin-rich repeat, [[3g39]] }}
+
<StructureSection load='' size='350' side='right' scene='45/456531/Cv/1' caption='Variable lymphocyte receptor of lamprey (grey) bound to a protein antigen (green) ([[3g3a]]), resolution 2.20&Aring;'>
'''Variable lymphocyte receptors''' (VLRs) are [[leucine-rich repeat]] (LRR) family proteins that mediate adaptive immune responses in the jawless vertebrates, lampreys and hagfish. <ref>PMID: 17192264</ref>
'''Variable lymphocyte receptors''' (VLRs) are [[leucine-rich repeat]] (LRR) family proteins that mediate adaptive immune responses in the jawless vertebrates, lampreys and hagfish. <ref>PMID: 17192264</ref>
-
[[Image:3g3a biol unitsurf.png|370px|right|thumb| [[Lamprey Variable Lymphocyte Receptor]] in complex with a protein antigen ([[3g3a]])]]
 
-
{{STRUCTURE_3g3a| PDB=3g3a | SCENE=Variable_Lymphocyte_Receptors/3g3a_biological_unit/3 |CAPTION= Variable lymphocyte receptor of lamprey (grey) bound to a protein antigen (green) ([[3g3a]]), resolution 2.20&Aring;}}
+
<scene name='45/456531/Cv/3'>Leucines highlighted in magenta</scene>.
-
__TOC__
+
-
Articles in Proteopedia concerning Variable lymphocyte receptors include:
+
[[Image:3g3a biol unitsurf.png|370px|left|thumb| [[Lamprey Variable Lymphocyte Receptor]] in complex with a protein antigen ([[3g3a]])]]
-
*[[Lamprey Variable Lymphocyte Receptor]]
+
{{Clear}}
-
 
+
-
 
+
-
==References==
+
-
<references/>
+
==See Also==
==See Also==
 +
*[[Lamprey Variable Lymphocyte Receptor]]
*[[leucine-rich repeat|Leucine-rich Repeat Proteins]]
*[[leucine-rich repeat|Leucine-rich Repeat Proteins]]
*[[Antibody]]
*[[Antibody]]
*[[Forkhead box protein]]
*[[Forkhead box protein]]
 +
==3D structures of variable lymphocyte receptor==
 +
[[Variable lymphocyte receptor 3D structures]]
 +
</StructureSection>
 +
 +
Articles in Proteopedia concerning Variable lymphocyte receptors include:
 +
*[[Lamprey Variable Lymphocyte Receptor]]
==Additional Literature==
==Additional Literature==
<ref group="xtra">PMID: 21293377</ref><ref group="xtra">PMID: 20660361</ref><ref group="xtra">PMID: 20482318</ref><ref group="xtra">PMID: 19543291</ref><ref group="xtra">PMID: 20660361</ref> <ref group="xtra">PMID: 18238899 </ref><ref group="xtra">PMID: 18818359 </ref><references group="xtra"/>See [[Lamprey Variable Lymphocyte Receptor]] for details.
<ref group="xtra">PMID: 21293377</ref><ref group="xtra">PMID: 20660361</ref><ref group="xtra">PMID: 20482318</ref><ref group="xtra">PMID: 19543291</ref><ref group="xtra">PMID: 20660361</ref> <ref group="xtra">PMID: 18238899 </ref><ref group="xtra">PMID: 18818359 </ref><references group="xtra"/>See [[Lamprey Variable Lymphocyte Receptor]] for details.
-
 
+
==References==
-
==3D structures of variable lymphocyte receptor==
+
<references/>
-
 
+
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
-
 
+
-
[[3m19]], [[3g39]], [[2r9u]], [[3wo9]], [[4k5u]], [[4k79]] - mlVLR ectodomain – marine lamprey<br />
+
-
[[3m18]], [[3g3a]] – mlVLR ectodomain + lysozyme<br />
+
-
[[3g3b]] - mlVLR ectodomain (mutant) + lysozyme<br />
+
-
[[3e6j]] - mlVLR ectodomain + trisaccharide<br />
+
-
[[2o6q]], [[2o6r]], [[2o6s]] – IhVLR leucine-rich repeat – inshore hagfish<br />
+
-
[[2z62]], [[2z63]], [[2z66]] – IhVLR/hTLR4<br />
+
-
[[3ul7]], [[3ul8]], [[3ul9]] – IhVLR/hTLR4 (mutant)<br />
+
-
[[3ula]] – IhVLR/hTLR4 (mutant) + eritoran<br />
+
-
[[2z80]], [[2z81]], [[2z82]], [[3a78]], [[3a7c]] – IhVLR/hTLR2<br />
+
-
[[2z65]] – IhVLR/hTLR4 + lymphocyte antigen 96<br />
+
-
[[2z7x]] – IhVLR/hTLR1 + IhVLR/hTLR2 + tri-acylated lipopeptide<br />
+
-
[[3a79]] - IhVLR/hTLR2 + IhVLR/hTLR6 + tri-acylated lipopeptide<br />
+
-
[[3twi]] – VLR B antigen-binding domain + BCLA protein – ''Bacillus anthracis''<br />
+
-
 
+
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Variable lymphocyte receptor of lamprey (grey) bound to a protein antigen (green) (3g3a), resolution 2.20Å

Drag the structure with the mouse to rotate

Articles in Proteopedia concerning Variable lymphocyte receptors include:

Additional Literature

  • Bajoghli B, Guo P, Aghaallaei N, Hirano M, Strohmeier C, McCurley N, Bockman DE, Schorpp M, Cooper MD, Boehm T. A thymus candidate in lampreys. Nature. 2011 Feb 3;470(7332):90-4. PMID:21293377 doi:10.1038/nature09655
  • Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
  • Mariuzza RA, Velikovsky CA, Deng L, Xu G, Pancer Z. Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates. Biol Chem. 2010 Jul;391(7):753-60. PMID:20482318 doi:10.1515/BC.2010.091
  • Velikovsky CA, Deng L, Tasumi S, Iyer LM, Kerzic MC, Aravind L, Pancer Z, Mariuzza RA. Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat Struct Mol Biol. 2009 Jul;16(7):725-30. Epub 2009 Jun 21. PMID:19543291 doi:10.1038/nsmb.1619
  • Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
  • Herrin BR, Alder MN, Roux KH, Sina C, Ehrhardt GR, Boydston JA, Turnbough CL Jr, Cooper MD. Structure and specificity of lamprey monoclonal antibodies. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2040-5. Epub 2008 Jan 31. PMID:18238899 doi:10.1073/pnas.0711619105
  • Han BW, Herrin BR, Cooper MD, Wilson IA. Antigen recognition by variable lymphocyte receptors. Science. 2008 Sep 26;321(5897):1834-7. PMID:18818359 doi:321/5897/1834
See Lamprey Variable Lymphocyte Receptor for details.

References

  1. ↑ Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee H, Yoo OJ, Kasahara M, Lee JO. Structural diversity of the hagfish variable lymphocyte receptors. J Biol Chem. 2007 Mar 2;282(9):6726-32. Epub 2006 Dec 27. PMID:17192264 doi:10.1074/jbc.M608471200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Variable_lymphocyte_receptor"
Personal tools