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3j78

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==Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class I - non-rotated ribosome with 2 tRNAs)==
==Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class I - non-rotated ribosome with 2 tRNAs)==
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<StructureSection load='3j78' size='340' side='right' caption='[[3j78]], [[Resolution|resolution]] 6.30&Aring;' scene=''>
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<SX load='3j78' size='340' side='right' viewer='molstar' caption='[[3j78]], [[Resolution|resolution]] 6.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3j78]] is a 84 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vxz 1vxz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J78 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3j78]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vxx 1vxx], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vxy 1vxy] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vxz 1vxz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J78 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vxx|1vxx]], [[1vxy|1vxy]], [[1vxz|1vxz]], [[3j77|3j77]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j78 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j78 RCSB], [http://www.ebi.ac.uk/pdbsum/3j78 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j78 OCA], [https://pdbe.org/3j78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j78 RCSB], [https://www.ebi.ac.uk/pdbsum/3j78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j78 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/RL2A_YEAST RL2A_YEAST]
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The structural understanding of eukaryotic translation lags behind that of translation on bacterial ribosomes. Here, we present two subnanometer resolution structures of S. cerevisiae 80S ribosome complexes formed with either one or two tRNAs and bound in response to an mRNA fragment containing the Kozak consensus sequence. The ribosomes adopt two globally different conformations that are related to each other by the rotation of the small subunit. Comparison with bacterial ribosome complexes reveals that the global structures and modes of intersubunit rotation of the yeast ribosome differ significantly from those in the bacterial counterpart, most notably in the regions involving the tRNA, small ribosomal subunit, and conserved helix 69 of the large ribosomal subunit. The structures provide insight into ribosome dynamics implicated in tRNA translocation and help elucidate the role of the Kozak fragment in positioning an open reading frame during translation initiation in eukaryotes.
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Structures of Yeast 80S Ribosome-tRNA Complexes in the Rotated and Nonrotated Conformations.,Svidritskiy E, Brilot AF, Koh CS, Grigorieff N, Korostelev AA Structure. 2014 Jul 16. pii: S0969-2126(14)00178-6. doi:, 10.1016/j.str.2014.06.003. PMID:25043550<ref>PMID:25043550</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
==See Also==
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
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== References ==
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*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
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<references/>
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__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Brilot, A F]]
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[[Category: Brilot AF]]
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[[Category: Grigorieff, N]]
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[[Category: Grigorieff N]]
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[[Category: Koh, C S]]
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[[Category: Koh CS]]
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[[Category: Korostelev, A A]]
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[[Category: Korostelev AA]]
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[[Category: Svidritskiy, E]]
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[[Category: Svidritskiy E]]
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[[Category: 80s ribosome]]
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[[Category: Classical-state]]
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[[Category: Hybrid-state]]
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[[Category: Kozak sequence]]
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[[Category: Ribosome]]
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[[Category: Translation]]
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[[Category: Trna]]
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Current revision

Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class I - non-rotated ribosome with 2 tRNAs)

3j78, resolution 6.30Å

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