4u4q

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==Crystal structure of Homoharringtonine bound to the yeast 80S ribosome==
==Crystal structure of Homoharringtonine bound to the yeast 80S ribosome==
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<StructureSection load='4u4q' size='340' side='right' caption='[[4u4q]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='4u4q' size='340' side='right'caption='[[4u4q]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4u4q]] is a 162 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_atcc_204508_/_s288c Saccharomyces cerevisiae atcc 204508 / s288c]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ul8 4ul8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U4Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4u4q]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ul4 4ul4], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ul5 4ul5], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ul6 4ul6], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ul7 4ul7] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ul8 4ul8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U4Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HMT:(3BETA)-O~3~-[(2R)-2,6-DIHYDROXY-2-(2-METHOXY-2-OXOETHYL)-6-METHYLHEPTANOYL]CEPHALOTAXINE'>HMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OHX:OSMIUM+(III)+HEXAMMINE'>OHX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HMT:(3BETA)-O~3~-[(2R)-2,6-DIHYDROXY-2-(2-METHOXY-2-OXOETHYL)-6-METHYLHEPTANOYL]CEPHALOTAXINE'>HMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OHX:OSMIUM+(III)+HEXAMMINE'>OHX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ul4|4ul4]], [[4ul5|4ul5]], [[4ul6|4ul6]], [[4ul7|4ul7]], [[4ul8|4ul8]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4q OCA], [https://pdbe.org/4u4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u4q RCSB], [https://www.ebi.ac.uk/pdbsum/4u4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u4q ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u4q RCSB], [http://www.ebi.ac.uk/pdbsum/4u4q PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RS6A_YEAST RS6A_YEAST] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4u4q" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
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*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Saccharomyces cerevisiae atcc 204508 / s288c]]
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[[Category: Large Structures]]
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[[Category: Loubresse, N Garreau de]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Prokhorova, I]]
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[[Category: Garreau de Loubresse N]]
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[[Category: Yusupov, M]]
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[[Category: Prokhorova I]]
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[[Category: Yusupova, G]]
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[[Category: Yusupov M]]
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[[Category: Antibiotic]]
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[[Category: Yusupova G]]
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[[Category: Eukaryote]]
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[[Category: Inhibitor]]
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[[Category: Ribosome]]
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[[Category: Rna-protein complex]]
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[[Category: Translation]]
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Current revision

Crystal structure of Homoharringtonine bound to the yeast 80S ribosome

PDB ID 4u4q

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