3j6y

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==S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I)==
==S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I)==
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<StructureSection load='3j6y' size='340' side='right' caption='[[3j6y]], [[Resolution|resolution]] 6.10&Aring;' scene=''>
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<SX load='3j6y' size='340' side='right' viewer='molstar' caption='[[3j6y]], [[Resolution|resolution]] 6.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3j6y]] is a 80 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vwv 1vwv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J6Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3j6y]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_W303 Saccharomyces cerevisiae W303]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vws 1vws], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vwu 1vwu] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vwv 1vwv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J6Y FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3j6x|3j6x]], [[1vws|1vws]], [[1vwu|1vwu]], [[1vwv|1vwv]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j6y RCSB], [http://www.ebi.ac.uk/pdbsum/3j6y PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6y OCA], [https://pdbe.org/3j6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j6y RCSB], [https://www.ebi.ac.uk/pdbsum/3j6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6y ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/RL1A_YEAST RL1A_YEAST]
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In cap-dependent translation initiation, the open reading frame (ORF) of mRNA is established by the placement of the AUG start codon and initiator tRNA in the ribosomal peptidyl (P) site. Internal ribosome entry sites (IRESs) promote translation of mRNAs in a cap-independent manner. We report two structures of the ribosome-bound Taura syndrome virus (TSV) IRES belonging to the family of Dicistroviridae intergenic IRESs. Intersubunit rotational states differ in these structures, suggesting that ribosome dynamics play a role in IRES translocation. Pseudoknot I of the IRES occupies the ribosomal decoding center at the aminoacyl (A) site in a manner resembling that of the tRNA anticodon-mRNA codon. The structures reveal that the TSV IRES initiates translation by a previously unseen mechanism, which is conceptually distinct from initiator tRNA-dependent mechanisms. Specifically, the ORF of the IRES-driven mRNA is established by the placement of the preceding tRNA-mRNA-like structure in the A site, whereas the 40S P site remains unoccupied during this initial step.
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Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA-like structural element in the ribosomal decoding center.,Koh CS, Brilot AF, Grigorieff N, Korostelev AA Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9139-44. doi:, 10.1073/pnas.1406335111. Epub 2014 Jun 9. PMID:24927574<ref>PMID:24927574</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==See Also==
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</div>
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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== References ==
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*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
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<references/>
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__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Large Structures]]
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[[Category: Brilot, A F]]
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[[Category: Saccharomyces cerevisiae W303]]
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[[Category: Grigorieff, N]]
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[[Category: Brilot AF]]
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[[Category: Koh, C S]]
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[[Category: Grigorieff N]]
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[[Category: Korostelev, A A]]
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[[Category: Koh CS]]
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[[Category: Intergenic ire]]
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[[Category: Korostelev AA]]
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[[Category: Ribosome]]
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[[Category: Translation initiation]]
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[[Category: Tsv ire]]
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Current revision

S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I)

3j6y, resolution 6.10Å

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