4u4r

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==Crystal structure of Lactimidomycin bound to the yeast 80S ribosome==
==Crystal structure of Lactimidomycin bound to the yeast 80S ribosome==
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<StructureSection load='4u4r' size='340' side='right' caption='[[4u4r]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='4u4r' size='340' side='right'caption='[[4u4r]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4u4r]] is a 162 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_atcc_204508_/_s288c Saccharomyces cerevisiae atcc 204508 / s288c]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ujt 4ujt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U4R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4u4r]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ujp 4ujp], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ujq 4ujq], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ujr 4ujr], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ujs 4ujs] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ujt 4ujt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U4R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3H3:4-{(2R,5S,6E)-2-HYDROXY-5-METHYL-7-[(2R,3S,4E,6Z,10E)-3-METHYL-12-OXOOXACYCLODODECA-4,6,10-TRIEN-2-YL]-4-OXOOCT-6-EN-1-YL}PIPERIDINE-2,6-DIONE'>3H3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OHX:OSMIUM+(III)+HEXAMMINE'>OHX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.801&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3H3:4-{(2R,5S,6E)-2-HYDROXY-5-METHYL-7-[(2R,3S,4E,6Z,10E)-3-METHYL-12-OXOOXACYCLODODECA-4,6,10-TRIEN-2-YL]-4-OXOOCT-6-EN-1-YL}PIPERIDINE-2,6-DIONE'>3H3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OHX:OSMIUM+(III)+HEXAMMINE'>OHX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ujp|4ujp]], [[4ujq|4ujq]], [[4ujr|4ujr]], [[4ujs|4ujs]], [[4ujt|4ujt]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4r OCA], [https://pdbe.org/4u4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u4r RCSB], [https://www.ebi.ac.uk/pdbsum/4u4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u4r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u4r RCSB], [http://www.ebi.ac.uk/pdbsum/4u4r PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL9A_YEAST RL9A_YEAST]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4u4r" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
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*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Saccharomyces cerevisiae atcc 204508 / s288c]]
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[[Category: Large Structures]]
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[[Category: Loubresse, N Garreau de]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Prokhorova, I]]
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[[Category: Garreau de Loubresse N]]
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[[Category: Yusupov, M]]
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[[Category: Prokhorova I]]
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[[Category: Yusupova, G]]
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[[Category: Yusupov M]]
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[[Category: Antibiotic]]
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[[Category: Yusupova G]]
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[[Category: Eukaryote]]
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[[Category: Inhibitor]]
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[[Category: Ribosome]]
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[[Category: Rna-protein complex]]
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[[Category: Translation]]
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Current revision

Crystal structure of Lactimidomycin bound to the yeast 80S ribosome

PDB ID 4u4r

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