3fku

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==Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10==
==Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10==
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<StructureSection load='3fku' size='340' side='right' caption='[[3fku]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='3fku' size='340' side='right'caption='[[3fku]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fku]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FKU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fku]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Viet_Nam/1203/2004(H5N1)) Influenza A virus (A/Viet Nam/1203/2004(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FKU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ibx|2ibx]], [[2fk0|2fk0]], [[2ghw|2ghw]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11320 Influenza A virus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fku OCA], [https://pdbe.org/3fku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fku RCSB], [https://www.ebi.ac.uk/pdbsum/3fku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fku ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fku RCSB], [http://www.ebi.ac.uk/pdbsum/3fku PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEMA_I03A0 HEMA_I03A0] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/3fku_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/3fku_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fku ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3fku" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Antibody|Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Hemagglutinin|Hemagglutinin]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Influenza a virus]]
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[[Category: Large Structures]]
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[[Category: Aird, D]]
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[[Category: Aird D]]
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[[Category: Ali, M]]
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[[Category: Ali M]]
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[[Category: Bankston, L A]]
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[[Category: Bankston LA]]
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[[Category: Cadwell, G]]
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[[Category: Cadwell G]]
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[[Category: Chen, L M]]
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[[Category: Chen LM]]
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[[Category: Cox, N]]
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[[Category: Cox N]]
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[[Category: Donis, R O]]
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[[Category: Donis RO]]
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[[Category: Han, T]]
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[[Category: Han T]]
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[[Category: Hwang, W C]]
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[[Category: Hwang WC]]
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[[Category: Liddington, R C]]
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[[Category: Liddington RC]]
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[[Category: Marasco, W A]]
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[[Category: Marasco WA]]
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[[Category: Murakami, A]]
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[[Category: Murakami A]]
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[[Category: Perez, S]]
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[[Category: Perez S]]
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[[Category: Santelli, E]]
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[[Category: Santelli E]]
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[[Category: Stec, B]]
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[[Category: Stec B]]
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[[Category: Sui, J]]
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[[Category: Sui J]]
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[[Category: Wei, G]]
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[[Category: Wei G]]
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[[Category: Yammanuru, A]]
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[[Category: Yammanuru A]]
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[[Category: Cell membrane]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Envelope protein]]
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[[Category: F10]]
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[[Category: Fusion protein]]
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[[Category: Glycoprotein]]
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[[Category: H5]]
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[[Category: Hemagglutinin]]
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[[Category: Influenza]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Neutralizing antibody]]
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[[Category: Palmitate]]
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[[Category: Scfv]]
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[[Category: Transmembrane]]
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[[Category: Viral protein]]
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[[Category: Viral protein-immune system complex]]
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[[Category: Virion]]
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Current revision

Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10

PDB ID 3fku

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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