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2l3y

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==Solution structure of mouse IL-6==
==Solution structure of mouse IL-6==
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<StructureSection load='2l3y' size='340' side='right' caption='[[2l3y]], [[NMR_Ensembles_of_Models | 52 NMR models]]' scene=''>
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<StructureSection load='2l3y' size='340' side='right'caption='[[2l3y]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L3Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3Y FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Il6, Il-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 52 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l3y RCSB], [http://www.ebi.ac.uk/pdbsum/2l3y PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3y OCA], [https://pdbe.org/2l3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3y RCSB], [https://www.ebi.ac.uk/pdbsum/2l3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3y ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL6_MOUSE IL6_MOUSE] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.<ref>PMID:16990136</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2l3y" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Interleukin|Interleukin]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Carr, M D]]
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[[Category: Carr MD]]
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[[Category: Carrington, B]]
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[[Category: Carrington B]]
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[[Category: Henry, A J]]
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[[Category: Henry AJ]]
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[[Category: Muskett, F W]]
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[[Category: Muskett FW]]
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[[Category: Redpath, N T]]
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[[Category: Redpath NT]]
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[[Category: Taylor, R J]]
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[[Category: Taylor RJ]]
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[[Category: Veverka, V]]
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[[Category: Veverka V]]
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[[Category: Cytokine]]
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[[Category: Gp-130]]
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[[Category: Interleukin]]
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[[Category: Signaling]]
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[[Category: Transcription]]
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Current revision

Solution structure of mouse IL-6

PDB ID 2l3y

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