3ckz

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==N1 Neuraminidase H274Y + Zanamivir==
==N1 Neuraminidase H274Y + Zanamivir==
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<StructureSection load='3ckz' size='340' side='right' caption='[[3ckz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='3ckz' size='340' side='right'caption='[[3ckz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ckz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CKZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ckz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Viet_Nam/1203/2004(H5N1)) Influenza A virus (A/Viet Nam/1203/2004(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CKZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cl0|3cl0]], [[3cl2|3cl2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ckz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckz OCA], [https://pdbe.org/3ckz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ckz RCSB], [https://www.ebi.ac.uk/pdbsum/3ckz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ckz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ckz RCSB], [http://www.ebi.ac.uk/pdbsum/3ckz PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NRAM_I04A1 NRAM_I04A1] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.[HAMAP-Rule:MF_04071]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/3ckz_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/3ckz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ckz ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3ckz" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Avian Influenza Neuraminidase%2C Tamiflu and Relenza|Avian Influenza Neuraminidase%2C Tamiflu and Relenza]]
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
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*[[Molecular Playground/Authoring|Molecular Playground/Authoring]]
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*[[Molecular Playground/Relenza|Molecular Playground/Relenza]]
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*[[Neuraminidase|Neuraminidase]]
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Exo-alpha-sialidase]]
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[[Category: Large Structures]]
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[[Category: Influenza a virus]]
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[[Category: Colllins P]]
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[[Category: Colllins, P]]
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[[Category: Gamblin SJ]]
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[[Category: Gamblin, S J]]
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[[Category: Haire LF]]
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[[Category: Haire, L F]]
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[[Category: Hay AJ]]
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[[Category: Hay, A J]]
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[[Category: Lin YP]]
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[[Category: Lin, Y P]]
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[[Category: Liu J]]
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[[Category: Liu, J]]
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[[Category: Martin SR]]
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[[Category: Martin, S R]]
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[[Category: Russell RJ]]
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[[Category: Russell, R J]]
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[[Category: Skehel JJ]]
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[[Category: Skehel, J J]]
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[[Category: Walker PA]]
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[[Category: Walker, P A]]
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[[Category: Glycosidase]]
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[[Category: H274y]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: N1]]
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[[Category: Neuraminidase]]
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[[Category: Transmembrane]]
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[[Category: Viral protein]]
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[[Category: Virion]]
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[[Category: Zanamivir]]
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Current revision

N1 Neuraminidase H274Y + Zanamivir

PDB ID 3ckz

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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