2gtt
From Proteopedia
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==Crystal structure of the rabies virus nucleoprotein-RNA complex== | ==Crystal structure of the rabies virus nucleoprotein-RNA complex== | ||
| - | <StructureSection load='2gtt' size='340' side='right' caption='[[2gtt]], [[Resolution|resolution]] 3.49Å' scene=''> | + | <StructureSection load='2gtt' size='340' side='right'caption='[[2gtt]], [[Resolution|resolution]] 3.49Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2gtt]] is a 24 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2gtt]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Rabies_lyssavirus Rabies lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GTT FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.49Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gtt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gtt OCA], [https://pdbe.org/2gtt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gtt RCSB], [https://www.ebi.ac.uk/pdbsum/2gtt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gtt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NCAP_RABVE NCAP_RABVE] Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2gtt" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Nucleoprotein|Nucleoprotein]] | + | *[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Rabies | + | [[Category: Large Structures]] |
| - | [[Category: Albertini | + | [[Category: Rabies lyssavirus]] |
| - | [[Category: Muziol | + | [[Category: Albertini AAV]] |
| - | [[Category: Ravelli | + | [[Category: Muziol T]] |
| - | [[Category: Ruigrok | + | [[Category: Ravelli RBG]] |
| - | [[Category: Weissenhorn | + | [[Category: Ruigrok RWH]] |
| - | [[Category: Wernimont | + | [[Category: Weissenhorn W]] |
| - | + | [[Category: Wernimont AK]] | |
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Current revision
Crystal structure of the rabies virus nucleoprotein-RNA complex
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